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. 2022 Oct 19;8:84. doi: 10.1038/s41522-022-00348-2

Fig. 4. Changes of metabolic profiles of the older women after treatment with L. reuteri.

Fig. 4

a The score plot of principal components analysis (PCA) based on metabolomic profiles in the GR (n = 10) and PR (n = 10) groups at baseline and 12 months. The blue and red colors indicate the GR and PR groups, respectively; The dot and triangle indicate the baseline (0 M) and 12 months (12 M), respectively. b Biological processes in which the differential metabolites are involved (P < 0.01 by the Wilcoxon test). c The left heatmap shows scaled mean abundances of the differential metabolites in the PR (n = 10) and GR (n = 10) groups at two time points. The blue and red colors indicate the low and high abundances, respectively; The grey color in the right heatmap indicates P-value of comparative analysis; ‘*’ denotes P < 0.05; ‘**’ denotes P < 0.01. d Association between metabolite hyocholate and the species E. coli. The blue line and grey shade indicate the regression line and 95% confidence interval; R denotes Spearman’s correlation coefficient.