Table 6.
Age-, sex- and body fat %-adjusted linear mixed regression estimates (standardized β coefficients (95% CI)) between MRS-measured LFC, body composition and cardiometabolic risk factors.
| LFC MRSa (%) | ||||
|---|---|---|---|---|
| Model 1 | Model 2 | |||
| β | p | β | p | |
| Body fat, % | 0.50 (0.10, 0.89) | 0.02 | ||
| Waist, cm | 0.58 (0.31, 0.85) | 0.0001 | 0.55 (0.20, 0.91) | 0.003 |
| BMI, kg/m2 | 0.34 (0.05, 0.64) | 0.03 | 0.17 (− 0.23, 0.57) | 0.40 |
| SBP, mmHg | − 0.08 (− 0.41, 0.26) | 0.64 | − 0.11 (− 0.42, 0.20) | 0.49 |
| DBP, mmHg | 0.13 (− 0.18, 0.45) | 0.40 | 0.08 (− 0.23, 0.38) | 0.61 |
| Resting heart rate, bpm | − 0.21 (− 0.52, 0.11) | 0.19 | − 0.19 (− 0.47, 0.09) | 0.18 |
| BP medication | 0.08 (− 0.26, 0.42) | 0.65 | 0.02 (− 0.31, 0.34) | 0.90 |
| Cholesterol medication | − 0.06 (− 0.38, 0.26) | 0.70 | 0.02 (− 0.29, 0.32) | 0.91 |
| f-Glucose, mmol/l | − 0.11 (− 0.44, 0.21) | 0.49 | − 0.13 (− 0.43, 0.17) | 0.40 |
| f-Insulin, mU/l | 0.41 (0.09, 0.72) | 0.01 | 0.31 (− 0.02, 0.63) | 0.06 |
| HOMA-IR | 0.38 (0.06, 0.70) | 0.02 | 0.28 (− 0.004, 0.60) | 0.084 |
| M-value, mg/kg/min | − 0.43 (− 0.72, − 0.14) | 0.005 | − 0.34 (− 0.67, − 0.01) | 0.047 |
| HbA1c, mmol/mol | 0.54 (0.27, 0.81) | 0.0003 | 0.48 (0.20, 0.75) | 0.001 |
| Triglycerides, mmol/l | 0.38 (0.09, 0.67) | 0.01 | 0.38 (0.11, 0.64) | 0.006 |
| Cholesterol, mmol/l | 0.22 (− 0.10, 0.53) | 0.18 | 0.22 (− 0.07, 0.52) | 0.14 |
| HDL, mmol/l | − 0.18 (− 0.57, 0.17) | 0.29 | − 0.18 (− 0.52, 0.17) | 0.31 |
| LDL, mmol/l | 0.18 (− 0.13, 0.49) | 0.25 | 0.18 (− 0.12, 0.47) | 0.23 |
| ALT, U/l | 0.50 (0.23, 0.78) | 0.0007 | 0.46 (0.20, 0.73) | 0.001 |
| AST, U/l | 0.24 (− 0.10, 0.59) | 0.16 | 0.32 (− 0.003, 0.64) | 0.052 |
| GGT, U/l | 0.30 (− 0.01, 0.60) | 0.054 | 0.29 (0.01, 0.57) | 0.04 |
Model 1 adjusted for age and sex.
Model 2 adjusted for age, sex and body fat %
ALT alanine aminotransferase, AST aspartate aminotransferase, BP blood pressure, DBP diastolic blood pressure, f fasting, GGT γ-glutamyltransferase, HbA1c hemoglobin A1c, HOMA-IR homeostatic model assessment for insulin resistance, LFC liver fat content, MRS magnetic resonance spectroscopy, M-value whole-body insulin sensitivity, SBP systolic blood pressure.
alog10 transformed variables.
Significant values are in bold.