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. 2022 Oct 19;12:17440. doi: 10.1038/s41598-022-22156-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Schematic illustration of claudin-3 mediated melanoma tumor lymphangiogenesis. Claudin-3 on LEC affects cell migration via the PI3K signaling pathway. Loss of claudin-3 leads to increased phosphorylation of AKT and ERK leading to increased tumor lymphangiogenesis accompanied with more melanoma cell B16F10 metastasis into draining lymph nodes. Created with Adobe Illustrator (CC 2017; https://www.adobe.com/products/illustrator.html).