Table 1.
Clinical characteristics and MSC bioenergetics by BPD Status.
| Characteristic | N | None/mild, N = 181 | Mod/sev, N = 211 | p value2 |
|---|---|---|---|---|
| GA (weeks) | 39 | 26.00 [25.25, 27.00] | 25.00 [24.00, 26.00] | 0.2 |
| Birth weight (g) | 39 | 870 [704, 980] | 690 [595, 840] | 0.036 |
| Sex (female) | 39 | 10 [56%] | 9 [43%] | 0.4 |
| Intrauterine growth restriction | 39 | 3 [17%] | 5 [24%] | 0.7 |
| Ethnicity | 39 | 0.002 | ||
| Caucasian | 3 [17%] | 14 [67%] | ||
| African-American | 15 [83%] | 7 [33%] | ||
| Histologic chorioamnionitis | 39 | 17 [94%] | 2 [9.5%] | < 0.001 |
| Preeclampsia/PIH/eclampsia | 39 | 5 [28%] | 8 [38%] | 0.5 |
| Maternal smoking | 39 | 7 [39%] | 7 [33%] | 0.7 |
| Basal OCR (pmol/min/30 k cells) | 29 | 67 [47, 98] | 36 [27, 44] | < 0.001 |
| ATP-linked OCR (pmol/min/30 k cells) | 29 | 36 [28, 45] | 14 [12, 21] | < 0.001 |
| Non-mitochondrial OCR (pmol/min/30 k cells) | 29 | 11 [9, 22] | 16 [11, 21] | 0.5 |
| Leak OCR (pmol/min/30 k cells) | 29 | 16 [9, 25] | 5 [4, 7] | < 0.001 |
| Maximal OCR (pmol/min/30 k cells) | 29 | 143 [101, 209] | 73 [70, 82] | < 0.001 |
| Spare respiratory capacity (pmol/min/30 k cells) | 29 | 62 [45, 99] | 37 [32, 46] | 0.003 |
| Complex IV OCR (pmol/min/30 k cells) | 29 | 125 [79, 170] | 63 [30, 93] | 0.023 |
| MSC ATP content (pMol/cell) | 29 | 29.82 [26.81, 30.21] | 25.23 [23.70, 26.70] | < 0.001 |
| Basal ECAR (mpH/min/30 k cells) | 29 | 37 [36, 45] | 52 [46, 60] | < 0.001 |
| Glycolytic capacity (mpH/min/30 k cells) | 29 | 56 [45, 66] | 82 [61, 95] | 0.004 |
1Median [IQR]; n [%] 2Student's t-test; Pearson's Chi-squared test; Wilcoxon rank sum exact test.
Significant values are in [bold].