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. 2022 Oct 19;13:6204. doi: 10.1038/s41467-022-33906-5

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Female (orange) and male (blue) composition of cohorts. b age and, c body mass index (BMI) distribution in cohorts. d ordination of skin microbiome profiles based on Bray-Curtis dissimilarity and principal coordinates analysis. Samples (n = 1,656) were colored by the skin site and represent dry [dorsal (D.) forearm (n = 260) and volar (V.) forearm (n = 251)], moist [antecubital (A.) fossa (n = 318 in KORA FF4, n = 258 in PopGen)] and sebaceous [seb.; forehead (n = 252) and retroauricular (R.) fold (n = 317)] microenvironments. Cohort names were abbreviated, PopGen (P) and KORA FF4 (K). Marginal boxplots are shown to visualize sample distributions along axes. The boxplot area represents the interquartile range (IQR) divided by the median. Lines extend to a maximum of 1.5 × IQR beyond the area. Points are outliers. Percentage of variation explained by each axis is shown in parentheses.