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. 2022 Oct 6;9:966707. doi: 10.3389/fcvm.2022.966707

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Copyright © 2022 Chen, Lu, Chen, Wang and Ma.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inverse-variance–weighted Mendelian randomization was performed to determine whether the genetic liability to cannabis use disorder is related to cardiovascular disease. OR, odds ratio. Estimates and p-value were from the random-effect inverse variance-weighted method. CI, confidence interval. The q-values represent Benjamini-Hochberg’s FDR-corrected p-value. The horizontal line represented the odds ratio and 95% confidence interval, OR < 1.0 indicated the risk of diseases decreased and OR > 1.0 indicated the risk of diseases increased. *One SNP (rs72818514) was excluded in the pulmonary embolism outcome because no available proxy was found.