Table 4.

Associations between cortisol and CSF AD biomarkers

	Aβ42			T-Tau			P-Tau
	b	95% CI	P	b	95% CI	p	b	95% CI	p
All (n=135)
Awakening cortisol (t1)	2.96	−68.57 to 74.49	0.935	0.06	−0.09 to 0.21	0.439	0.01	−0.11 to 0.14	0.818
Bedtime cortisol (t6)	21.67	−17.67 to 61.01	0.278	0.05	−0.04 to 0.13	0.272	0.02	−0.05 to 0.08	0.620
Cortisol awakening response	−3.22	−34.11 to 27.68	0.837	0.01	−0.06 to 0.07	0.778	0.01	−0.04 to 0.06	0.681
Daily cortisol output	12.23	−47.61 to 72.07	0.687	0.11	−0.02 to 0.23	0.089	0.07	−0.04 to 0.17	0.200
Cortisol AM/PM ratio (t1/t6)	−27.05	−83.17 to 29.07	0.342	–0.03	−0.15 to 0.08	0.585	−0.01	−0.11 to 0.08	0.798

Results based on linear regressions. All analysis adjusted for age, sex and education.

*P<0.05, **p<0.01; ***p<0.001.

AD, Alzheimer’s disease; Aβ, beta-amyloid; CSF, cerebrospinal fluid; P-Tau, phosphorylated tau; T-TAU, total tau.