TABLE 1.
Characteristics of multicenter subjects
| Brain age modeling data set | Clinical data sets | p Value | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Data set | ADNI | OASIS | IXI | SLIM | INDI | ADNI | ADNI | PPMI | PPMI | ADNI | PPMI |
| Category | HC | HC | HC | HC | HC | sMCI | pMCI | HC | Prodromal PD | sMCI vs. pMCI | HC vs. prodromal PD |
| No of subject | 1444 | 1136 | 461 | 453 | 680 | 69 | 64 | 171 | 174 | ‐ | ‐ |
| Female/Male | 751/693 | 696/440 | 256/205 | 287/166 | 371/309 | 28/41 | 26/38 | 65/106 | 97/77 | ‐ | ‐ |
| Age (years) | 76.43 ± 6.37 | 67.71 ± 8.81 | 51.18 ± 15.99 | 44.91 ± 17.57 | 25.82 ± 10.71 | 76.10 ± 6.77 | 76.95 ± 6.89 | 60.45 ± 11.68 | 61.06 ± 7.53 | .477 | .574 |
| MMSE | ‐ | ‐ | ‐ | ‐ | ‐ | 27.88 ± 1.84 | 25.50 ± 2.38 | ‐ | ‐ | <.001*** | ‐ |
| CDR | ‐ | ‐ | ‐ | ‐ | ‐ | 0.5 ± 0.0 | 0.5 ± 0.06 | ‐ | ‐ | .301 | ‐ |
| UPDRS III | ‐ | ‐ | ‐ | ‐ | ‐ | ‐ | ‐ | 0.92 ± 1.94 | 2.64 ± 3.95 | ‐ | <.001*** |
| ESS | ‐ | ‐ | ‐ | ‐ | ‐ | ‐ | ‐ | 5.42 ± 3.41 | 5.37 ± 3.37 | ‐ | .891 |
| RBDSQ | ‐ | ‐ | ‐ | ‐ | ‐ | ‐ | ‐ | 2.89 ± 2.29 | 4.14 ± 2.98 | ‐ | <.001*** |
Note: All data are presented in mean ± SD mode, and p values are significant of p < .05 (uncorrected for Tukey HSD test). *, p < .05; **, p < .01; ***, p < .001.
Abbreviations: CDR, Clinical Dementia Rating; ESS, Epworth Sleepiness Score; HSD, honestly significant difference; MMSE, Mini‐Mental State Examination; RBDSQ, REM (Rapid Eye Movement) Sleep Behavior Disorder Screening Questionnaire; UPDRS III, Movement Disorder Society‐Sponsored Revision of the Unified Parkinson Disease Rating Scale (MDS‐UPDRS), part III.