Receiver operating characteristic curve identified the cutoff point of neutrophil-to-lymphocyte ratio (NLR). (A) Baseline and preoperative NLR for predicting pathological complete response (pCR) were 1.96 (area under the curve [AUC], 0.679; sensitivity, 0.86; specificity, 0.50] and 1.89 (AUC, 0.657; sensitivity, 0.60; specificity, 0.75) in neoadjuvant chemotherapy combined with immunotherapy group. (B) Baseline and preoperative NLR for predicting major pathologic response (MPR) were 2.05 (AUC, 0.664; sensitivity, 0.829; specificity, 0.500) and 1.93 (AUC, 0.594; sensitivity, 0.575; specificity, 0.684) in neoadjuvant chemotherapy combined with immunotherapy group. (C) Baseline and preoperative NLR for predicting pCR were 1.01 (AUC, 0.433; sensitivity, 0.97; specificity, 0.25) and 1.43 (AUC, 0.516; sensitivity, 0.61; specificity, 0.63) in neoadjuvant chemotherapy alone group. (D) Preoperative NLR for predicting MPR were 1.01 (AUC, 0.422; sensitivity, 0.968; specificity, 0.154) and 1.43 (AUC, 0.615; sensitivity, 0.694; specificity, 0.615) in neoadjuvant chemotherapy alone group.