Table 2.
The correlation between pathological response and hematologic parameters in the two different neoadjuvant treatment groups
| Characteristic | Neoadjuvant chemotherapy combined with immunotherapy group | Neoadjuvant chemotherapy group | ||||||
|---|---|---|---|---|---|---|---|---|
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|
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| pCR (n=28) | Non-pCR (n=51) | Total | p-value | pCR (n=8) | Non-pCR (n=81) | Total | p-value | |
| Baseline WBC (×109/L) | 6.69 (4.99–12.18) | 8.12 (3.35–23.56) | 7.42 (3.35–23.56) | 0.009 | 7.19 (4.95–12.47) | 7.05 (3.23–18.99) | 7.06 (3.23–18.99) | 0.605 |
|
| ||||||||
| Baseline neutrophils (×109/L) | 3.93 (2.34–9.01) | 5.60 (1.73–19.24) | 4.80 (1.73–19.24) | 0.001 | 4.70 (1.94–10.85) | 4.32 (1.5–12.53) | 4.38 (1.50–12.53) | 0.789 |
|
| ||||||||
| Baseline monocytes (×109/L) | 0.51 (0.11–1.03) | 0.56 (0.06–5.90) | 0.53 (0.06–5.90) | 0.166 | 0.52 (0.27–0.84) | 0.53 (0.09–1.13) | 0.53 (0.09–1.13) | 0.746 |
|
| ||||||||
| Baseline lymphocyte (×109/L) | 2.10 (1.16–3.75) | 1.84 (0.78–3.99) | 1.90 (0.78–3.99) | 0.335 | 1.92 (0.73–3.52) | 1.88 (0.82–5.07) | 1.89 (0.73–5.07) | 0.817 |
|
| ||||||||
| Baseline platelet (×109/L) | 248.50 (103.00–387.00) | 286.00 (146.00–541.00) | 267.00 (103.00–541.00) | 0.026 | 272.00 (145.00–317.00) | 277.00 (160.00–563.00) | 273.00 (145.00–563.00) | 0.733 |
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| ||||||||
| Baseline NLR | 2.00 (0.85–4.76) | 2.88 (1.20–13.23) | 2.61 (0.85–13.23) | 0.009 | 2.74 (0.77–14.86) | 2.25 (0.86–6.28) | 2.31 (0.77–14.86) | 0.537 |
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| ||||||||
| Preoperative WBC (×109/L) | 5.30 (3.80–15.36) | 6.47 (2.43–12.66) | 5.86 (2.43–15.36) | 0.035 | 5.28 (4.39–7.29) | 6.14 (3.06–15.70) | 5.99 (3.06–15.70) | 0.128 |
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| ||||||||
| Preoperative neutrophils (×109/L) | 2.76 (1.21–13.65) | 3.31 (1.04–9.34) | 3.19 (1.04–13.65) | 0.013 | 2.86 (2.27–3.58) | 3.37 (0.58–12.63) | 3.32 (0.58–12.63) | 0.127 |
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| ||||||||
| Preoperative monocytes (×109/L) | 0.56 (0.30–1.08) | 0.60 (0.18–1.35) | 0.58 (0.18–1.35) | 0.059 | 0.48 (0.33–0.93) | 0.57 (0.24–1.44) | 0.56 (0.24–1.44) | 0.134 |
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| ||||||||
| Preoperative lymphocyte (×109/L) | 2.06 (0.63–2.79) | 1.73 (0.79–3.09) | 1.83 (0.63–3.09) | 0.632 | 1.78 (0.84–3.30) | 2.03 (0.47–3.83) | 2.02 (0.47–3.83) | 0.851 |
|
| ||||||||
| Preoperative platelet (×109/L) | 222.00 (93.00–690.00) | 237.50 (147.00–384.00) | 233.50 (93.00–690.00) | 0.186 | 215.50 (166.00–260.00) | 230.00 (117.00–509.00) | 224.00 (117.00–509.00) | 0.489 |
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| ||||||||
| Preoperative NLR | 1.63 (0.53–21.67) | 2.02 (0.79–7.52) | 1.83 (0.53–21.67) | 0.022 | 1.38 (0.85–6.20) | 1.83 (0.21–17.68) | 1.69 (0.21–17.68) | 0.880 |
Values are presented as median (range). NLR, neutrophil-to-lymphocyte ratio; pCR, pathological complete response; WBC, white blood cell.