Table 1.
Characteristics of the study subjects at baseline
| Variable | Total (n=294) | MOS methylation level (n=261) | p-value | |
|---|---|---|---|---|
| Low (n=99) | High (n=162) | |||
| Age (yr) | 63.2±8.7 | 62.4±9.1 | 64.1±8.6 | 0.132 |
| Male sex | 200 (68.0) | 68 (68.7) | 108 (66.7) | 0.735 |
| Follow-up duration (day) | 998.1±670.1 | 1,250.5±712.4 | 837.4±589.8 | < 0.001 |
| No. of endoscopic follow-up | 3.6±2.4 | 4.4±2.7 | 3.1±2.1 | < 0.001 |
| Helicobacter pylori positive | 110 (37.4) | 33 (33.3) | 63 (38.9) | 0.366 |
| Current or ex-smoker | 127 (43.2) | 57 (47.9) | 62 (52.1) | 0.572 |
| Current or ex-drinker | 158 (53.7) | 70 (48.3) | 75 (51.7) | 0.787 |
| Family history of GC in 1° relatives | 49 (17.4) | 20 (20.6) | 25 (16.2) | 0.378 |
| Body mass index (kg/m 2 ) | 24.4±3.2 | 24.3±3.5 | 24.4±3.0 | 0.678 |
| Education | ||||
| Elementary-Middle-High | 149 (65.6) | 62 (72.1) | 79 (64.2) | 0.232 |
| University | 78 (34.4) | 24 (27.9) | 55 (35.8) | |
| Pathology | ||||
| Low-grade dysplasia | 147 (50.0) | 44(44.9) | 77 (48.7) | 0.662 |
| High-grade dysplasia | 24 (8.2) | 7 (7.1) | 14 (8.9) | |
| Adenocarcinoma | 123 (41.8) | 47 (48.0) | 67 (42.4) | |
| OLGA stage | ||||
| Stage 0 | 26 (22.4) | 11 (28.2) | 13 (18.3) | 0.760 |
| Stage 1 | 28 (24.1) | 8 (20.5) | 18 (25.4) | |
| Stage 2 | 28 (24.1) | 8 (20.5) | 19 (26.8) | |
| Stage 3 | 22 (19.0) | 8 (20.5) | 13 (18.3) | |
| Stage 4 | 12 (10.3) | 4 (10.3) | 8 (11.8) | |
| OLGIM stage | ||||
| Stage 0 | 51 (17.3) | 21 (21.6) | 25 (16.0) | 0.430 |
| Stage 1 | 59 (20.1) | 16 (16.5) | 35 (22.4) | |
| Stage 2 | 87 (29.6) | 34 (35.1) | 44 (28.2) | |
| Stage 3 | 52 (17.7) | 15 (15.5) | 30 (19.2) | |
| Stage 4 | 35 (11.9) | 11 (11.3) | 22 (14.1) | |
| Synchronous EGCs/dysplasia a) | 25 (10.2) | 8 (8.7) | 16 (10.9) | |
Values are presented as mean±SD or number (%). p-values were calculated using chi-square test or Student’s t test. The cutoff value (35.82%) of high or low MOS methylation levels was determined by receiver operating curve analysis. Statistically significant at p < 0.001. EGC, early gastric cancer; GC, gastric cancer; OLGA, operative link on gastritis assessment; OLGIM, operative link on gastric intestinal metaplasia assessment; SD, standard deviation.
a)
Synchronous lesions were defined as secondary dysplasia or cancers detected within 1 year after initial diagnosis.