Table 2.

Univariate and multivariate Cox proportional regression analyses of the metachronous recurrence (n=124)

	Crude HR (95% CI)	p-value	p for trend	Adjusted HRa) (95% CI)	p-valuea)	p for trend
MOS high b)	4.73 (1.56–14.40)	0.006c)		4.76 (1.54–14.79)	0.007c)
Atrophic gastritis	1.40 (0.18–10.88)	0.746		1.31 (0.16–10.75)	0.802
Intestinal metaplasia	2.62 (0.35–19.74)	0.349		2.32 (0.30–18.29)	0.423
MOS quartile
Q1	1 (reference)			1 (reference)
Q2	1.64 (0.41–6.61)	0.485		1.42 (0.35–5.87)	0.624
Q3	3.36 (0.87–13.03)	0.080		3.11 (0.78–12.46)	0.109
Q4	3.53 (1.02–12.22)	0.047	0.027c)	3.29 (0.94–11.53)	0.062	0.034c)
OLGA stage
0	1 (reference)			1 (reference)
1	1.79 (0.18–17.56)	0.615		1.65 (0.13–20.16)	0.697
2	0.61 (0.04–9.90)	0.728		0.57 (0.03–10.28)	0.705
3	0.60 (0.04–27.31)	0.719		0.51 (0.02–10.59)	0.665
4	1.56 (0.09–27.31)	0.761	0.689	1.63 (0.09–30.55)	0.745	0.677
OLGIM stage
0	1 (reference)			1 (reference)
1	3.26 (0.38–27.93)	0.282		2.95 (0.33–26.56)	0.334
2	2.22 (0.27–18.54)	0.461		2.10 (0.24–18.20)	0.503
3	2.21 (0.24–20.15)	0.481		1.75 (0.18–16.83)	0.627
4	3.78 (0.42–34.44)	0.238	0.452	3.38 (0.34–33.17)	0.297	0.617

CI, confidence interval; HR, hazard ratio; OLGA, operative link on gastritis assessment; OLGIM, operative link on gastric intestinal metaplasia assessment.

^a)Adjusted for age, sex, Helicobacter pylori infection status, and smoking,

^b)The cutoff value (35.82%) of high or low MOS methylation levels was determined by receiver operating curve analysis. Atrophic gastritis and intestinal metaplasia were defined as the presence of histologic atrophy (score 1–3) and intestinal metaplasia (score 1–3), respectively, at either antrum or corpus by the updated Sydney scoring system,

^c)Statistically significant.