Fig. 1.

Consort diagram of desmoid tumor patients included in this study. Prospective phase II study with treatment of imatinib included 20 patients after excluding two patients with clinical concerns. Tumor samples from 11 patients, which passed stringent quality check, were whole-genome-sequenced. RNA-sequencing (RNA-seq) was performed for 29 cases, including seven in phase II study and 22 in retrospective cohort, of which 11 cases were treated with imatinib. QC, quality control; WGS, whole-genome sequencing.