. 2021 Nov 17;54(4):1081–1090. doi: 10.4143/crt.2021.890

Table 2.

Cox regression model for risk factors of recurrence in early breast cancer

	Total				DCIS				IDC

	Univariate		Multivariate		Univariate		Multivariate		Univariate		Multivariate

	HR (95% CI)	p-value	HR (95% CI)	p-value	HR (95% CI)	p-value	HR (95% CI)	p-value	HR (95% CI)	p-value	HR (95% CI)	p-value
Age (yr)

< 50	Reference		Reference		Reference		Reference		Reference		Reference

≥ 50	0.51 (0.35–0.73)	< 0.001	0.46 (0.32–0.66)	< 0.001	0.29 (0.12–0.72)	0.007	0.29 (0.12–0.72)	0.007	0.57 (0.38–0.86)	0.007	0.53 (0.36–0.80)	0.002

Type

DCIS	Reference

IDC	1.20 (0.80–1.80)	0.390	-	-	-	-	-	-	-	-	-	-

Grade

1	Reference		Reference						Reference		Reference

2	2.06 (1.10–3.87)	0.025	1.90 (1.00–3.61)	0.050	-	-	-	-	2.06 (1.10–3.87)	0.025	1.89 (0.99–3.61)	0.054

3	3.07 (1.65–5.73)	< 0.001	2.18 (1.05–4.52)	0.036	-	-	-	-	3.08 (1.65–5.73)	< 0.001	2.12 (0.99–4.54)	0.052

LVI

No	Reference								Reference

Yes	1.46 (0.90–2.37)	0.131	-	-	-	-	-	-	1.46 (0.90–2.37)	0.130	-	-

ER

ER^high	Reference		Reference		Reference				Reference		Reference

ER^low	1.34 (0.49–3.65)	0.571	0.95 (0.50–1.82)	0.882	1.31 (0.18–9.63)	0.793	-	-	1.36 (0.43–4.33)	0.606	1.09 (0.29–4.14)	0.897

ER⁻	1.96 (1.35–2.85)	< 0.001	0.94 (0.34–2.64)	0.907	0.74 (0.23–2.46)	0.626	-	-	2.29 (1.52–3.44)	< 0.001	1.27 (0.36–4.44)	0.707

PR

Positive	Reference				Reference				Reference		Reference

Negative	1.20 (1.00–1.43)	0.054	-	-	0.81 (0.48–1.37)	0.426	-	-	1.62 (1.09–2.42)	0.018	0.52 (0.21–1.33)	0.175

HER2

Positive	Reference								Reference

Negative	0.76 (0.27–2.19)	0.613	-	-	-	-	-	-	0.77 (0.38–1.57)	0.477	-	-

Ki-67

< 14	Reference		Reference		Reference				Reference		Reference

≥ 14	1.66 (1.18–2.34)	0.004	1.00 (0.64–1.57)	0.989	1.13 (0.46–2.76)	0.794	-	-	1.79 (1.21–2.64)	0.003	0.99 (0.60–1.65)	0.971

HT

No	Reference		Reference		Reference				Reference		Reference

Yes	0.50 (0.35–0.70)	< 0.001	0.45 (0.25–0.79)	0.006	0.75 (0.37–1.54)	0.754	-	-	0.40 (0.27–0.59)	< 0.001	0.30 (0.12–0.77)	0.012

CT

No	Reference								Reference

Yes	1.06 (0.73–1.52)	0.777	-	-	-	-	-	-	1.00 (0.67–1.50)	0.985	-	-

CI, confidence interval; CT, chemotherapy; DCIS, ductal carcinoma in situ; ER, estrogen receptor; ER⁻, estrogen receptor negative; ER^high, estrogen receptor high positive; ER^low, estrogen receptor low positive; HER2, human epidermal growth factor receptor 2; HR, hazard ratio; HT, hormonal therapy; IDC, invasive ductal carcinoma; LVI, lymphovascular invasion; PR, progesterone receptor.