Table 3.
Biopsy naïve (BN = green box) and previous-negative-biopsy (PNB = grey box) patients and relations to the biopsy technique (combined biopsy (TB/SB), target biopsy (TB) and systematic biopsy (SB) and “Prostate Imaging–Reporting and Data System Version 2 (PI-RADS) 2–5 evaluating radiologist report. Clinically significant (cs) prostate cancer (PCa) or insignificant (is) PCa was defined according to the “European Association of Urologists” risk groups.
| Characteristics | BN | PNB | p |
|---|---|---|---|
| Total, n (%; median, IQR, min.-max.) | 499 (61) | 314 (39; 1, 1–2, 1–6) | |
| PI-RADS 2, n (%) | 11 (2) | 25 (8) | 0.0001 |
| PI-RADS 3, n (%) | 112 (22) | 89 (28) | 0.06 |
| PI-RADS 4, n (%) | 236 (47) | 128 (42) | 0.07 |
| PI-RADS 5, n (%) | 140 (28) | 72 (23) | 0.1 |
| csPCa detection (TB/SB) PI-RADS 2, n (%) | 1 (9) | 2 (8) | 0.9 |
| csPCa detection (TB/SB) PI-RADS 3, n (%) | 38 (34) | 23 (26) | 0.2 |
| csPCa detection (TB/SB) PI-RADS 4, n (%) | 155 (66) | 67 (52) | 0.01 |
| csPCa detection (TB/SB) PI-RADS 5, n (%) | 116 (83) | 43 (60) | 0.0002 |
| overall PCa detection TB/SB, n (%) | 356 (71) | 155 (49) | <0.0001 |
| cs PCa detection TB/SB, n (%) | 310 (62) | 135 (43) | <0.0001 |
| cs PCa detection TB, n (%) | 268 (54) | 107 (34) | <0.0001 |
| cs PCa detection SB, n (%) | 283 (57) | 108 (34) | <0.0001 |
| cs PCa detection solely by TB total cohort, n (%) | 21 (4) | 22 (7) | 0.08 |
| cs PCa detection solely by TB csPCa-cohort, n (%) | 21 (7) | 22 (16) | 0.002 |
| cs PCa detection solely by SB total cohort, n (%) | 34 (7) | 26 (8) | 0.44 |
| cs PCa detection solely by SB csPCa-cohort, n (%) | 34 (11) | 26 (19) | 0.02 |
| cs PCa detection simultaneously by TB/SB, n (%) | 255 (82) | 87 (64) | <0.0001 |
| Is PCa detection TB/SB, n (%) | 46 (9) | 20 (6) | 0.1 |
| Is PCa detection TB, n (%) | 37 (7) | 10 (3) | 0.01 |
| Is PCa detection SB, n (%) | 47 (9) | 21 (7) | 0.2 |
| Whole mount pathology ISUP score after RP | |||
| ISUP 1, n (%) | 6 (5) | 2 (5) | 0.8 |
| ISUP 2, n (%) | 39 (36) | 11 (27) | 0.3 |
| ISUP 3, n (%) | 42 (38) | 15 (36) | 0.9 |
| ISUP 4, n (%) | 9 (8) | 7 (17) | 0.1 |
| ISUP 5, n (%) | 14 (13) | 6 (15) | 0.8 |
International Society of Urological Pathology (ISUP), Radical prostatectomy (RP).
Bold p-values indicate clinical significance.