Table 4.

Accurracy of Target Biopsy (TB), Systematic Biopsy (SB) and combined biopsy (TB/SB) to predict the International Society of Uropathological Pathology (ISUP) score of the whole-mount pathology report (WMPR) of patients who consented radical prostatectomy (n = 151). Agreement = dark green, upgrading = red, downgrading = yellow. Not applicable (n.a.).

	Total TB/SB	BN TB/SB	PNB TB/SB	p BN vs. PNB TB/SB	Total TB	BN TB	PNB TB	p BN vs. PNB TB	Total SB	BN SB	PNB SB	p BN vs. PNB SB	p Total TB/SB vs.TB/SB / TB vs.SB	p BN TB/SB vs.TB/SB / TB vs.SB	p PNB TB/SB vs.TB/SB / TB vs.SB
ISUP Agreement with WMPR, n (%)	80 (53)	61 (55)	19 (46)	0.3	61 (40)	45 (41)	16 (39)	0.8	63 (42)	52 (47)	11 (27)	0.02	0.001/ 0.001 / 0.8	0.003/0.01 / 0.3	0.2/0.03 / 0.3
ISUP Upgrading with WMPR, n (%)	43 (28)	28 (25)	15 (37)	0.2	75 (50)	55 (50)	20 (49)	0.9	68 (45)	41 (37)	27 (66)	0.002	<0.0001/<0.0001/ 0.4	<0.0001/0.0003/ 0.02	0.03/0.0005 / 0.09
Upgrading ISUP 1 to ISUP ≥2 by WMPR, n (%)	14 (9)	10 (9)	4 (10)	0.9	19 (13)	15 (14)	4 (10)	0.5	20 (13)	14 (13)	6 (15)	0.8	0.09/0.03 / 0.8	0.1/0.03 / 0.05	1/0.3 / 0.3
Upgrading ISUP 2 to ISUP ≥3 by WMPR, n (%)	20 (13)	13 (12)	7 (17)	0.4	26 (17)	18 (16)	8 (20)	0.6	22 (15)	14 (13)	8 (20)	0.3	0.03/0.5 / 0.3	0.03/0.7 / 0.2	0.6/0.7 / 1
ISUP Downgrading with WMPR, n (%)	28 (19)	21 (19)	7 (17)	0.8	15 (10)	10 (9)	5 (12)	0.6	20 (13)	17 (15)	3 (7)	0.2	0.003/0.005 / 0.3	0.001/0.045 / 0.1	0.2/0.045 / 0.4
Downgrading to ISUP 2 by WMPR, n (%)	14 (9)	11 (10)	3 (7)	0.6	6 (4)	5 (4)	1 (2)	0.6	11 (7)	9 (8)	2 (5)	0.5	0.005/0.08 / 0.1	0.01/0.2 / 0.2	0.2/0.3 / 0.6
Downgrading to ISUP 1 by WMPR, n (%)	2 (1)	2 (2)	0	0.4	0	0	0	-	2 (1)	2 (2)	0	0.4	n.a./1 / n.a.	n.a./1 / n.a.	n.a./n.a. / n.a.

Biopsy Naïve (BN)- or Previous-Negative Biopsy (PNB)-cohort.

Bold p-values indicate clinical significance.