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(A) Schematic representation of different modes of cellular regulation influencing mitotic activity of CDK1. The activation of CDK1 is directly regulated by cyclin B binding, phosphorylation by WEE1/MYT1 kinases, dephosphorylation by Cdc25 phosphatases and the binding of CDK inhibitors. CDK1’s activity is also indirectly affected by transcription regulation impinging on cyclin expression and the proteolytic degradation of cyclins and CDK inhibitors.
