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. 2022 Oct 15;37:143–151. doi: 10.1016/j.jot.2022.09.001

Figure 2.

Figure 2

Vascular formation was accelerated in rats with prevascularized macroporous β-TCP scaffolds in thesegmental tibial bone defect (A–C) Representative and quantitative analysis of CD31-, CD34-, and VEGF-A-immunostained sections from rats implanted with a blank or prevascularized b-TCP scaffold. The rats underwent consolidation for 8 weeks. Scale bars, 200 ​μm n ​= ​3 in each group. ∗p ​< ​0.05; ∗∗p ​< ​0.01; and ∗∗∗p ​< ​0.001 (D) Representative micro-CT images of the vessel network within regenerating bone in rats with a tibia bone defect at 2, 4, 6, and 8 weeks after implantation with a blank or prevascularized b-TCP scaffold. Scale bars, 1 ​mm. Two-way ANOVA with the Bonferroni post hoc test was used to determine significant differences among groups. n ​= ​3 in each group. ∗∗∗p ​< ​0.001 for the vascularization group vs the blank group in each week; #p ​< ​0.05 and ###p ​< ​0.001 for 4, 6, and 8 weeks vs 2 week in each group.