TABLE 3.

Meta-analysis of the association between genetic polymorphism and symptomatic lumbar disk herniation.

Genetic model	Overall effect		Heterogeneity		Publication bias		Analysis model	FPRP
IL-1α(+889C/T)	OR (95%CL)	P	I2	P	Begg’s	Egger’s		0.1	0.01	0.001
T vs. C	1.28 (1.03–1.6)	0.028	0	0.742	0.23	0.62	Fix	0.228	0.765	0.970
CT/TT vs. CC	1.23 (0.92–1.64)	0.167	0	0.876	0.133	0.189	Fix
TT vs. CC/CT	1.92 (1.16–3.17)	0.01	0	0.801	0.764	0.894	Fix	0.367	0.864	0.985
TT vs. CC	2.00 (1.19–3.38)	0.009	0	0.780	0.368	0.861	Fix	0.380	0.871	0.986
CT vs. CC	1.10 (0.81–1.49)	0.535	0	0.929	0.133	0.136	Fix
CILP (1184T>C)
C vs. T	1.01 (0.62–1.66)	0.959	91.5%	0.00	0.881	0.825	Random
CT/CC vs. TT	1.02 (0.60–1.73)	0.949	86.4%	0.001	0.764	0.887	Random
CC vs. TT/CT	1.00 (0.36–2.76)	0.997	89.4%	0.000	0.881	0.729	Random
CC vs. TT	0.98 (0.31–3.14)	0.972	90.9%	0.000	0.652	0.763	Random
CT vs. TT	1.05 (0.69–1.60)	0.825	76.3%	0.015	0.707	0.811	Random