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. 2022 Oct 6;9:1024790. doi: 10.3389/fcvm.2022.1024790

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Copyright © 2022 Toor, Aldous, Parray, Akhtar, Al-Sarraj, Abdelalim, Arredouani, El-Agnaf, Thornalley, Pananchikkal, Pir, Kuni, Shuaib, Alajez and Albagha.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Study cohort and analysis workflow. (A) The study comprised acute ischemic stroke patients with and without type 2 diabetes mellitus (SWDM; n = 92, SWoDM; n = 98). Patients were randomly divided into discovery and validation cohorts with comparable distribution of covariates (age, gender, diabetes and statin treatment). Statistically significant parameters (P < 0.05) between SWDM and SWoDM patients are marked with an asterisk (*). (B) Serum samples were collected within 24 h of clinical diagnosis of acute ischemic stroke from SWDM and SWoDM patients. Differentially regulated and statistically significant miRNAs detected in the discovery dataset generated from miRNA transcripts by RNA-Seq were investigated in the validation dataset. Combined analysis was then performed to identify FDR-significant miRNAs presented as validated differentially regulated miRNAs in SWDM compared to SWoDM patients.