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Receiver operating characteristic curves for NaPDoS and NaPDoS2. Nonredundant sets of 213 positive and 308 negative control KS domains were compared based on the BLASTP e-values of their closest non-self-match in each NaPDoS database. Optimal cutoff values were selected to maximize sensitivity. FP, false positives; KS, ketosynthase; NaPDoS2, Natural Product Domain Seeker version 2; TP, true positives.
