FIGURE 3.

Inhibiting increases in reactive oxygen species with MitoQ prevents hAβ_1–42-induced changes in mitochondrial and synaptic proteins. (A1) Representative immunoblots of superoxide dismutase 2 (SOD2), mitochondrial cytochrome c (Mito-cyt C), and the loading control β-Actin, are shown in slices treated with MitoQ, hAβ_1–42 with MitoQ, and control. (A2) Normalized relative expression of SOD2 and Mito-cyt C proteins (n = 6). (B1) Representative immunoblots of postsynaptic density protein PSD95, presynaptic marker synaptophysin (Synap.), vesicular acetylcholine transporter (VAChT), and the loading control β-Actin are shown in tissue treated with MitoQ, hAβ_1–42 with MitoQ, and control. Bar graphs indicate normalized relative expression of PSD95, Synap., and VAChT (B2).