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. 2022 Oct 6;14:960314. doi: 10.3389/fnagi.2022.960314

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Copyright © 2022 Olajide, La Rue, Bergdahl and Chapman.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inhibiting increases in reactive oxygen species with EUK134 prevents hAβ_1–42-induced changes in mitochondrial and synaptic proteins. (A1) Representative immunoblots of superoxide dismutase 2 (SOD2), mitochondrial cytochrome c (Mito-cyt C), and the loading control β-Actin, are shown in slices treated with EUK134, hAβ_1–42 with EUK134, and control. (A2) Normalized relative expression of SOD2 and Mito-cyt C proteins (n = 6). (B1) Representative immunoblots of postsynaptic density protein PSD95, presynaptic marker synaptophysin (Synap.), vesicular acetylcholine transporter (VAChT), and the loading control β-Actin are shown for tissue treated with EUK134, hAβ_1–42 with EUK134, and control. Bar graphs indicate normalized relative expression of PSD95, Synap., and VAChT (B2) (*p < 0.05).