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. 2022 Oct 6;13:1010554. doi: 10.3389/fimmu.2022.1010554

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Copyright © 2022 Xu, Nie, Lv, Chen, Wang, Wang, Zhao, He and Chen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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WNT-based subtypes are associated with the distinct tumor microenvironment. (A) Box plots presenting the infiltration score of CD8 T cells, Tregs, neutrophils, and macrophages. (B) Estimation of immune cell type fractions using different algorithms including ssGSEA, TIMER and MCP-counter. (C) Correlation between CD8 score and WNT3 expression. (D) Multiplex immunofluorescence validated the correlation between CD8⁺ T cell infiltration and WNT3 expression.