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. 2022 Oct 6;13:1010554. doi: 10.3389/fimmu.2022.1010554

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Copyright © 2022 Xu, Nie, Lv, Chen, Wang, Wang, Zhao, He and Chen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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WNT-high subtypes are associated with the immune suppressive tumor microenvironment. (A) Violin plots of immune checkpoint expression. (B) Estimated score of the seven-step cancer-immunity cycle. (C) Heatmap of gene expression associated with the negative regulation of the immune processes. (D) Bar plot of ICB response rate. (E) Box plot of TIDE score. (F) GSEA plot of the underlying biological processes associated with WNT subtypes. (ns, p > 0.05; *, p < 0.05; **, p < 0.01; ***, p < 0.001; ****, p < 0.0001).