Table 2.
Comparison of the antimicrobial susceptibility rates of K. pneumoniae isolates in clinical features.
| Antibiotic | %S | MIC50 | MIC90 | Gender (%) | Age (%) | Primary infection(%) | Bloodstream infection(%) | ICU admission(%) | Clinical outcome(%) | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Female N = 219 |
Male N = 393 |
p-value | ≤ 65 N = 401 | > 65 N = 200 | p-Value | CO N = 308 | HA N = 280 | p-Value | CO N = 292 | HA N = 317 | p-Value | Yes N = 196 |
No N = 416 |
p-Value | Death N = 55 |
Others N = 528 |
p-Value | ||||
| Polymyxin B | 97.1 | 0.5 | 0.5 | 96.3 | 97.5 | 0.437 | 97.3 | 96.4 | 0.575 | 97.7 | 97.9 | 0.915 | 96.9 | 97.2 | 0.860 | 96.9 | 97.1 | 0.904 | 94.5 | 97.2 | 0.236 |
| Colistin | 97.1 | 0.25 | 0.5 | 96.3 | 97.5 | 0.437 | 97.3 | 96.4 | 0.575 | 97.7 | 97.9 | 0.915 | 96.9 | 97.2 | 0.860 | 96.9 | 97.1 | 0.904 | 94.5 | 97.2 | 0.236 |
| Aztreonam/Avibactam | 99.8 | 0.064 | 0.064 | 100.0 | 99.7 | 1.000 | 100.0 | 99.5 | 0.722 | 100.0 | 99.6 | 0.962 | 100.0 | 99.7 | 1.000 | 99.5 | 100.0 | 0.700 | 98.2 | 100.0 | 0.165 |
| Ceftazidime/avibactam | 99.5 | 0.064 | 0.064 | 100.0 | 99.2 | 0.489 | 99.5 | 99.5 | 1.000 | 100.0 | 98.9 | 0.214 | 100.0 | 99.1 | 0.277 | 100.0 | 99.3 | 0.568 | 100.0 | 99.4 | 1.000 |
| Amikacin | 78.3 | 1 | 128 | 78.1 | 78.4 | 0.934 | 77.5 | 80.2 | 0.446 | 86.0 | 71.1 | 0.000* | 87.7 | 69.4 | 0.000* | 66.3 | 83.9 | 0.000* | 47.3 | 81.1 | 0.000* |
| Meropenem | 74.8 | 0.064 | 256 | 78.1 | 73.3 | 0.189 | 73.0 | 80.7 | 0.039* | 86.0 | 64.3 | 0.000* | 87.7 | 62.8 | 0.000* | 60.7 | 81.5 | 0.000* | 49.1 | 76.7 | 0.000* |
| Imipenem | 73.7 | 0.25 | 128 | 76.7 | 72.0 | 0.205 | 71.5 | 80.2 | 0.022* | 84.1 | 63.9 | 0.000* | 85.6 | 62.5 | 0.000* | 61.2 | 79.6 | 0.000* | 49.1 | 75.6 | 0.000* |
| Ertapenem | 71.4 | 0.064 | 256 | 74.0 | 70.0 | 0.294 | 70.0 | 76.1 | 0.118 | 82.1 | 61.1 | 0.000* | 83.9 | 59.6 | 0.000* | 57.7 | 77.9 | 0.000* | 45.5 | 73.3 | 0.000* |
| Piperacillin/Tazobactam | 71.4 | 8 | > 256 | 74.9 | 69.5 | 0.155 | 70.0 | 76.6 | 0.090 | 80.8 | 62.5 | 0.000* | 83.6 | 59.9 | 0.000* | 57.7 | 77.9 | 0.000* | 47.3 | 73.5 | 0.000* |
| Cefoperazone/Sulbactam | 67.2 | 8 | 256 | 65.3 | 68.2 | 0.465 | 66.6 | 70.1 | 0.394 | 77.9 | 56.8 | 0.000* | 80.1 | 54.9 | 0.000* | 51.5 | 74.5 | 0.000* | 36.4 | 69.3 | 0.000* |
| Cefoxitin | 64.7 | 2 | 128 | 64.8 | 64.6 | 0.959 | 63.6 | 69.0 | 0.190 | 75.6 | 55.4 | 0.000* | 76.7 | 53.9 | 0.000* | 53.1 | 70.2 | 0.000* | 34.5 | 67.2 | 0.000* |
| Sitafloxacin | 63.7 | 0.125 | 16 | 65.3 | 62.8 | 0.546 | 63.6 | 65.0 | 0.744 | 72.1 | 56.1 | 0.000* | 73.6 | 54.3 | 0.000* | 51.5 | 69.5 | 0.000* | 32.7 | 66.1 | 0.000* |
| Ceftazidime | 63.1 | 0.5 | 256 | 64.8 | 62.1 | 0.499 | 61.4 | 68.0 | 0.113 | 73.4 | 53.9 | 0.000* | 76.0 | 51.4 | 0.000* | 53.6 | 67.5 | 0.001* | 32.7 | 65.5 | 0.000* |
| Levofloxacin | 58.7 | 0.5 | 64 | 58.4 | 58.8 | 0.936 | 58.4 | 59.9 | 0.729 | 66.6 | 51.8 | 0.000* | 67.8 | 49.8 | 0.000* | 45.4 | 64.9 | 0.000* | 25.5 | 61.2 | 0.000* |
| Cefepime | 57.0 | 0.125 | 256 | 53.4 | 59.0 | 0.179 | 55.9 | 60.4 | 0.299 | 69.2 | 45.0 | 0.000* | 71.6 | 43.2 | 0.000* | 45.9 | 62.3 | 0.000* | 32.7 | 58.5 | 0.000* |
| Ceftriaxone | 52.9 | 0.25 | 256 | 48.4 | 55.5 | 0.093 | 52.0 | 55.8 | 0.374 | 66.6 | 39.6 | 0.000* | 68.8 | 38.5 | 0.000* | 43.9 | 57.2 | 0.002* | 25.5 | 54.7 | 0.000* |
| Trimethoprim/sulfamethoxazole | 52.0 | 2 | 8 | 48.4 | 53.9 | 0.188 | 52.2 | 51.3 | 0.825 | 60.1 | 42.5 | 0.000* | 62.0 | 42.3 | 0.000* | 49.0 | 53.4 | 0.311 | 40.0 | 52.3 | 0.083 |
*
p < 0.05.