Table 5.
Comparison of the antimicrobial susceptibility rates of E. cloacae isolates in clinical features.
| Antibiotic | %S | MIC50 | MIC90 | Gender (%) | Age (%) | Primary infection(%) | Bloodstream infection(%) | ICU admission(%) | Clinical outcome(%) | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Female N = 20 |
Male N = 38 |
p-Value | ≤ 65 N = 37 | > 65 N = 21 | p-Value | CO N = 18 | HA N = 38 | p-Value | CO N = 16 | HA N = 42 | p-Value | Yes N = 36 | No N = 22 | p-Value | Death N = 5 |
Others N = 50 |
p-Value | ||||
| Polymyxin B | 81.0 | 0.5 | 128 | 70.0 | 86.8 | 0.229 | 81.1 | 81.0 | 1.000 | 72.2 | 86.8 | 0.337 | 75.0 | 83.3 | 0.727 | 77.3 | 83.3 | 0.821 | 80.0 | 80.0 | 1.000 |
| Colistin | 79.3 | 0.25 | 128 | 70.0 | 84.2 | 0.353 | 81.1 | 76.2 | 0.917 | 70.2 | 84.2 | 0.487 | 75.0 | 81.0 | 0.891 | 72.7 | 83.3 | 0.526 | 60.0 | 80.0 | 0.298 |
| Ceftazidime/avibactam | 100.0 | 0.064 | 0.064 | 100.0 | 100.0 | - | 100.0 | 100.0 | - | 100.0 | 100.0 | - | 100.0 | 100.0 | - | 100.0 | 100.0 | - | 100.0 | 100.0 | - |
| Aztreonam/Avibactam | 98.3 | 0.064 | 0.125 | 100.0 | 97.4 | 1.000 | 97.3 | 100.0 | 1.000 | 100.0 | 100.0 | - | 100.0 | 97.6 | 1.000 | 100.0 | 97.2 | 1.000 | 100.0 | 98.0 | 1.000 |
| Amikacin | 96.6 | 1 | 4 | 95.0 | 97.4 | 1.000 | 94.6 | 100.0 | 0.530 | 94.4 | 100.0 | 0.321 | 93.8 | 97.6 | 0.479 | 100.0 | 94.4 | 0.521 | 100.0 | 96.0 | 1.000 |
| Meropenem | 91.4 | 0.064 | 0.25 | 85.0 | 94.7 | 0.328 | 86.5 | 100.0 | 0.148 | 88.9 | 94.7 | 0.587 | 87.5 | 92.9 | 0.609 | 90.9 | 91.7 | 1.000 | 100.0 | 90.0 | 1.000 |
| Ertapenem | 84.5 | 0.125 | 2 | 80.0 | 86.8 | 0.762 | 78.4 | 95.2 | 0.184 | 83.3 | 86.8 | 1.000 | 81.3 | 85.7 | 0.989 | 86.4 | 83.3 | 1.000 | 100.0 | 82.0 | 0.578 |
| Piperacillin/Tazobactam | 82.8 | 8 | 32 | 80.0 | 84.2 | 0.970 | 78.4 | 90.5 | 0.418 | 77.8 | 86.8 | 0.636 | 75.0 | 85.7 | 0.564 | 81.8 | 83.3 | 1.000 | 60.0 | 86.0 | 0.184 |
| Cefoperazone/Sulbactam | 82.8 | 8 | 32 | 80.0 | 84.2 | 0.970 | 78.4 | 90.5 | 0.418 | 77.8 | 84.2 | 0.831 | 75.0 | 85.7 | 0.564 | 72.7 | 88.9 | 0.221 | 40.0 | 88.0 | 0.027* |
| Imipenem | 79.3 | 0.5 | 4 | 65.0 | 86.8 | 0.107 | 75.7 | 85.7 | 0.569 | 72.2 | 84.2 | 0.487 | 75.0 | 81.0 | 0.891 | 81.8 | 77.8 | 0.972 | 100.0 | 78.0 | 0.571 |
| Sitafloxacin | 77.6 | 0.012 | 2 | 80.0 | 76.3 | 1.000 | 78.4 | 76.2 | 1.000 | 72.2 | 81.6 | 0.654 | 75.0 | 78.6 | 1.000 | 77.3 | 77.8 | 1.000 | 80.0 | 76.0 | 1.000 |
| Cefepime | 77.6 | 0.064 | 128 | 70.0 | 81.6 | 0.500 | 67.6 | 95.2 | 0.036* | 72.2 | 81.6 | 0.654 | 68.8 | 81.0 | 0.520 | 77.3 | 77.8 | 1.000 | 100.0 | 74.0 | 0.324 |
| Levofloxacin | 72.4 | 0.064 | 8 | 70.0 | 73.7 | 0.765 | 70.3 | 76.2 | 0.628 | 61.1 | 78.9 | 0.278 | 68.8 | 73.8 | 0.955 | 77.3 | 69.4 | 0.517 | 80.0 | 70.0 | 1.000 |
| Ceftazidime | 65.5 | 0.5 | 128 | 60.0 | 68.4 | 0.521 | 59.5 | 76.2 | 0.198 | 61.1 | 68.4 | 0.589 | 56.3 | 69.0 | 0.359 | 59.1 | 69.4 | 0.421 | 40.0 | 68.0 | 0.327 |
| Ceftriaxone | 51.7 | 1 | 256 | 55.0 | 50.0 | 0.717 | 43.2 | 66.7 | 0.086 | 55.6 | 50.0 | 0.698 | 50.0 | 52.4 | 0.871 | 40.9 | 58.3 | 0.198 | 20.0 | 56.0 | 0.178 |
| Trimethoprim/sulfamethoxazole | 48.3 | 4 | 8 | 45.0 | 50.0 | 0.717 | 37.8 | 66.7 | 0.035* | 55.6 | 44.7 | 0.449 | 56.3 | 45.2 | 0.453 | 59.1 | 41.7 | 0.198 | 60.0 | 46.0 | 0.659 |
| Cefoxitin | 10.3 | 128 | 128 | 15.0 | 7.9 | 0.405 | 10.8 | 9.5 | 1.000 | 5.6 | 13.2 | 0.652 | 0.0 | 14.3 | 0.173 | 4.5 | 13.9 | 0.392 | 0.0 | 12.0 | 1.000 |
*
p < 0.05.