TABLE 1.
Demographics and standard pulmonary function of CLAD subjects compared to time matched CLAD-free cohort.
| CLAD-free (n = 225) | CLAD (n = 38) | p-value | ||
|---|---|---|---|---|
| BOS (n = 32) | RAS (n = 6) | |||
| Male, n (%) | 136 (60.4) | 17 (53.1) | 4 (66.7) | 0.688 |
| Age, years | 60.0 [49.0, 66.0] | 54.5 [40.5, 61.5] | 63.5 [56.8, 68.8] | 0.094 |
| Height, m | 1.70 ± 0.1 | 1.67 ± 0.1) | 1.75 ± 0.1 | 0.107 |
| Weight, kg | 74.5 ± 16.7 | 81.0 ± 16.5 | 87.0 ± 14.1 | 0.030 |
| BMI, kg/m2 | 26.4 ± 4.9 | 29.0 ± 6.0 | 28.3 ± 4.6 | 0.019 |
| PRA Positive, n (%) | 108 (48.0) | 21 (65.6) | 3 (50.0) | 0.175 |
| VCM Positive, n (%) | 56 (24.9) | 9 (28.1) | 0 (0.0) | 0.337 |
| ACM Positive, n (%) | 22 (9.8) | 6 (18.8) | 0 (0.0) | 0.212 |
| CMV match status, n (%) | 0.685 | |||
| R−/D+ (mismatch) | 102 (45.3) | 18 (56.2) | 2 (33.3) | |
| R−/D− (negative) | 45 (20.0) | 6 (18.8) | 2 (33.3) | |
| R+/D+ (positive) | 78 (34.7) | 8 (25.0) | 2 (33.3) | |
| Primary disease, n (%) | ||||
| Pulmonary Fibrosis | 85 (37.8) | 10 (31.1) | 1 (16.7) | 0.165 |
| COPD/Emphysema | 69 (30.7) | 7 (21.9) | 3 (50.0) | |
| Cystic Fibrosis/Bronchiectasis | 24 (10.7) | 6 (18.8) | 1 (16.7) | |
| Other | 47 (20.9) | 9 (28.1) | 1 (16.7) | |
| Follow-up, days | 265.0 [168.0, 438.0] | 346.0 [195.8, 545.0] | 178.5 [163.3, 319.0] | 0.186 |
| Values at CLAD-onset or time-matched date | ||||
| FVC (L) | 3.04 ± 0.92 | 2.73 ± 1.16 | 2.58 ± 0.97 | 0.138 |
| %predicted | 75.47 ± 18.77 | 65.62 ± 21.44 | 56.77 ± 14.70 | 0.002 |
| FEV1 (L) | 2.34 ± 0.78 | 1.57 ± 0.67 | 2.04 ± 0.75 | <0.001 |
| %predicted | 74.21 ± 22.30 | 48.28 ± 20.11 | 57.73 ± 11.80 | <0.001 |
| FEV1/FVC (%) | 77.18 ± 12.89 | 58.23 ± 11.43 | 79.78 ± 6.31 | <0.001 |
| %predicted | 98.16 ± 16.40 | 72.88 ± 14.20 | 103.13 ± 9.09 | <0.001 |
| TLC (L) | 4.80 ± 1.17 | 4.78 ± 1.52 | 4.46 ± 1.03 | 0.825 |
| %predicted | 78.63 ± 16.47 | 77.09 ± 16.79 | 63.74 ± 15.13 | 0.129 |
| RV (L) | 1.72 ± 0.55 | 1.90 ± 0.49 | 1.65 ± 0.33 | 0.242 |
| %predicted | 88.32 ± 33.63 | 104.51 ± 37.28 | 75.46 ± 22.64 | 0.039 |
| RV/TLC (%) | 36.25 ± 8.71 | 41.24 ± 9.01 | 37.72 ± 8.36 | 0.018 |
| %predicted | 99.98 ± 29.71 | 122.81 ± 39.01 | 103.38 ± 17.22 | 0.001 |
| DLCO (ml/min/mmHg) | 15.35 ± 4.35 | 17.60 ± 5.50 | 11.17 ± 3.30 | 0.071 |
| %predicted | 71.57 ± 13.73 | 73.61 ± 16.58 | 65.57 ± 17.81 | 0.679 |
ACM, actual cross match; BMI, body mass index; CMV, cytomegalovirus; COPD, chronic obstructive lung disease; D, donor; DLCO, diffusing capacity for carbon monoxide; FEV1, forced expiratory volume in one second; FVC, forced vital capacity; PRA, panel of reactive antibodies; R, recipient; RV, residual volume; TLC, total lung capacity; VCM, virtual cross match. Continuous normal variables are reported as mean (SD); non-normal variables as median [IQR].