TABLE 2.

Effects and recommendations reported in the literature related to the secretion from Phyllomedusa bicolor.

age, sex	country	recommendation	signs and symptoms	symptoms of intoxication	outcome	reference
41 years, woman	Chile	Depression	Unresponsive, with extreme hypotonia of the limbs and hypoventilation	Severe neurologic effects, rhabdomyolysis and renal failure (on the second day)	Discharge	Alamos et al. (2020)
46 years, man	Bolivia	-	Subcutaneous lipoma	-	Discharge	Den Brave et al. (2014)
42 years, man	Greece	No recommendation	-	Left ventricular hypertrophy	Death	Aquila et al. (2017)
44 years, woman	Slovenia	-	Nausea and vomiting, confusion, lethargy, muscle weakness, spasms and cramps, seizure, decreased consciousness level and short-term memory loss	Neurological symptoms and hyponatremia result of inappropriate antidiuretic hormone secretion	Discharge	Leban et al. (2016)
34 years, mean	-	Abstinence from drinking, smoking, and to purify the body	Icterus, skin itching, weakness, and pain in the upper abdomen	Toxic hepatitis	Discharge	Pogorzelska and Łapiński (2017)
32 years, woman	-	-	Nausea, vomiting, and abdominal discomfort	Hyponatremia	Discharge	Kumachev et al. (2018)
24 years, woman		-	Nausea, vomiting, flushing, facial swelling, altered mental status, and extreme agitation	Prolonged toxicity (maintenance of symptoms after 22 h of use)	Discharge	Li et al. (2018)
33 years, woman		Alleviate chronic pain	Paranoia, anxiety, bizarre delusions, labile mood, and panic attacks	Psychosis	Discharge	Roy et al. (2018)
58 years, woman	-	Cholangiocarcinoma	Tachycardia, tachypnea, impaired liver cholestatic enzymes, and enlargement of lymphadenopathy mimicking disease progression	Systemic inflammatory response syndrome mimicking disease	Death	Peleg Hasson et al. (2021)
33 years, woman	Brazil	No recommendation	3-week history of asthenia, malaise, myalgia, and proximal muscle weakness, particularly in the lower limbs	Dermatomyositis	Discharge	De la Vega et al. (2020)
41 years, woman	Chile	-	Vomiting, profuse diarrhea, quantitatively compromised consciousness, and tonic-clonic convulsions	Hyponatremia	Discharge	Campodónico et al. (2019)
woman	-	-	Vomiting and liquid stools that were self-limited	Hyponatremia result of inappropriate antidiuretic hormone secretion	Discharge	Agüero-González et al. (2019)
62 years, woman	-	-	Shortness of breath, epigastric abdominal pain, nausea, and non-bloody emesis	Led to pneumothorax, septic shock, and esophageal rupture	-	Gonzaga et al. (2020)
37 years,woman a		Depression	Visual hallucination, agitation, tremors of extremities, oral paresthesia, seizures, nausea, vomiting, sweating and five skin lesions on the leg	Neurological symptoms	Discharge	Morais et al. (2018)

^aConcomitant ayahuasca and P. bicolor secretion use.