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. 2022 Oct 6;13:961817. doi: 10.3389/fphar.2022.961817

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Copyright © 2022 Zhang, Xue, Jing, Tian, Zhang, Li, Lu, Chen, Diao, Chen, Wang and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Diffusion tensor imaging (DTI) analysis of the bilateral hippocampus (L HIP, R HIP), prefrontal cortex (L PFC, R PFC), ventral tegmental area (L VTA, R VTA), and dorsal raphe nucleus (DRN) in the control group and the LPS-4 d group. (A) Fractional anisotropy (FA) in the control group and the LPS-4 d group. (B) Mean diffusivity (MD) in the control group and the LPS-4 d group. Data are expressed as the mean ± SEM (n = 6). **p < 0.01, ***p < 0.005, ****p < 0.001, compared to the control group.