Table 1.
Proteins and isoforms identified in samples of facial melasma (M) and adjacent photoexposed (P) skin (n = 40) with the difference between the groups (p ≤ 0.05 or ≥0.95) and M/P ratio ≥2.0 or ≤0.5.
| Protein code | Protein | PLGS score | Melasma | Perilesional | Log2 M/P (sd) | M/P ratio | p-Valuea |
|---|---|---|---|---|---|---|---|
| P1 | Actin Alpha Skeletal Muscle ACTA1 | 958.81 | 1.34 (0.04) | 0.66 (0.04) | 1.04 (0.07) | 2.05 | 1.00 |
| P2 | Actin Cytoplasmic 2 ACTG1 | 1164.96 | 1.40 (0.06) | 0.60 (0.06) | 1.23 (0.11) | 2.34 | 1.00 |
| Actin Cytoplasmic 2 ACTG1 | 1164.96 | 1.40 (0.07) | 0.60 (0.07) | 1.24 (0.12) | 2.36 | 1.00 | |
| P3 | A-Kinase Anchor Protein 13 AKAP13 | 87.85 | 1.53 (0.40) | 0.47 (0.40) | 1.96 (1.03) | 3.90 | 0.97 |
| A-Kinase Anchor Protein 13 AKAP13 | 87.85 | 1.55 (0.37) | 0.45 (0.37) | 1.99 (1.13) | 3.97 | 0.95 | |
| P4 | A-kinase Anchor protein 9 AKAP9 | 12.43 | 0.35 (0.34) | 1.65 (0.34) | −2.39 (1.00) | 0.19 | 0.03 |
| A-kinase Anchor protein 9 AKAP9 | 13.08 | 0.38 (0.20) | 1.62 (0.20) | −2.16 (0.50) | 0.22 | 0.00 | |
| A-kinase Anchor protein 9 AKAP9 | 16.30 | 0.40 (0.24) | 1.60 (0.24) | −2.06 (0.55) | 0.24 | 0.00 | |
| P5 | Albumin isoform CRA k ALB | 542.99 | 0.62 (0.05) | 1.38 (0.05) | −1.14 (0.08) | 0.45 | 0.00 |
| Serum albumin ALB | 5862.44 | 0.54 (0.18) | 1.46 (0.18) | −1.44 (0.32) | 0.37 | 0.00 | |
| Serum albumin ALB | 542.99 | 0.63 (0.04) | 1.37 (0.04) | −1.14 (0.07) | 0.45 | 0.00 | |
| Serum albumin ALB | 542.99 | 0.52 (0.07) | 1.48 (0.07) | −1.50 (0.12) | 0.35 | 0.00 | |
| Serum albumin ALB | 2923.53 | 0.62 (0.10) | 1.38 (0.10) | −1.17 (0.17) | 0.44 | 0.00 | |
| Serum albumin ALB | 542.99 | 0.63 (0.06) | 1.37 (0.06) | −1.11 (0.10) | 0.46 | 0.00 | |
| Serum albumin ALB | 486.61 | 0.64 (0.06) | 1.36 (0.06) | −1.07 (0.09) | 0.48 | 0.00 | |
| Serum albumin ALB | 534.91 | 0.66 (0.08) | 1.34 (0.08) | −1.04 (0.12) | 0.49 | 0.00 | |
| P6 | Alpha-1-antitrypsin SERPINA1 | 1092.60 | 1.33 (0.13) | 0.67 (0.13) | 1.00 (0.21) | 2.00 | 1.00 |
| P7 | Androglobin ADGB | 69.19 | 0.48 (0.21) | 1.52 (0.21) | −1.69 (0.40) | 0.31 | 0.05 |
| P8 | Annexin ANXA2 | 117.73 | 1.33 (0.25) | 0.67 (0.25) | 1.01 (0.41) | 2.01 | 0.95 |
| Annexin ANXA2 | 117.73 | 1.33 (0.26) | 0.67 (0.26) | 1.02 (0.44) | 2.03 | 0.97 | |
| Annexin ANXA2 | 117.73 | 1.34 (0.26) | 0.66 (0.26) | 1.05 (0.43) | 2.08 | 0.95 | |
| Annexin ANXA2 | 117.73 | 1.35 (0.28) | 0.65 (0.28) | 1.08 (0.43) | 2.12 | 0.95 | |
| P9 | Beta-actin-like protein 2 ACTBL2 | 101.00 | 1.43 (0.07) | 0.57 (0.07) | 1.34 (0.12) | 2.53 | 1.00 |
| P10 | BTB/POZ domain-containing protein KCTD7 | 53.81 | 1.57 (0.17) | 0.43 (0.17) | 1.90 (0.40) | 3.74 | 1.00 |
| P11 | Carbonic Anhydrase 1 CA1 | 1112.39 | 0.39 (0.17) | 1.61 (0.17) | −2.09 (0.45) | 0.23 | 0.00 |
| Carbonic Anhydrase 1 CA1 | 1386.45 | 0.47 (0.13) | 1.53 (0.13) | −1.70 (0.27) | 0.31 | 0.00 | |
| P12 | Ceruloplasmin CP | 76.55 | 1.40 (0.17) | 0.60 (0.17) | 1.23 (0.30) | 2.34 | 1.00 |
| Ceruloplasmin CP | 85.85 | 1.37 (0.17) | 0.63 (0.17) | 1.13 (0.29) | 2.18 | 1.00 | |
| Ceruloplasmin CP | 85.85 | 1.43 (0.15) | 0.57 (0.15) | 1.34 (0.27) | 2.53 | 1.00 | |
| P13 | DNA polymerase zeta catalytic subunit REV3L | 73.85 | 1.58 (0.34) | 0.42 (0.34) | 2.03 (0.86) | 4.10 | 0.95 |
| DNA polymerase zeta catalytic subunit REV3L | 153.25 | 1.52 (0.06) | 0.48 (0.06) | 1.66 (0.12) | 3.16 | 1.00 | |
| P14 | Exophilin-5 EXPH5 | 40.12 | 1.79 (0.12) | 0.21 (0.12) | 3.16 (0.48) | 8.94 | 1.00 |
| P15 | Fibrinogen Gamma chain FGG | 211.06 | 1.33 (0.16) | 0.67 (0.16) | 1.01 (0.25) | 2.01 | 1.00 |
| P16 | Fibrinogen Gamma chain FGG | 211.06 | 1.34 (0.14) | 0.66 (0.14) | 1.04 (0.24) | 2.05 | 1.00 |
| Fructose-bisphosphate Aldolase A ALDOA | 153.06 | 1.46 (0.07) | 0.54 (0.07) | 1.43 (0.14) | 2.69 | 1.00 | |
| Fructose-bisphosphate aldolase A ALDOA | 296.85 | 1.45 (0.07) | 0.55 (0.07) | 1.41 (0.13) | 2.66 | 1.00 | |
| Fructose-bisphosphate aldolase ALDOA | 295.30 | 1.46 (0.10) | 0.54 (0.10) | 1.43 (0.17) | 2.69 | 1.00 | |
| Fructose-bisphosphate aldolase ALDOA | 295.30 | 1.47 (0.08) | 0.53 (0.08) | 1.46 (0.14) | 2.75 | 1.00 | |
| P17 | G Patch domain-containing protein 1 GPATCH1 | 95.48 | 1.37 (0.14) | 0.63 (0.14) | 1.13 (0.25) | 2.18 | 1.00 |
| G patch domain-containing protein 1 GPATCH1 | 88.85 | 1.60 (0.28) | 0.40 (0.28) | 2.15 (0.66) | 4.44 | 1.00 | |
| P18 | Heat shock protein 75 kDa mitochondrial TRAP1 | 124.78 | 1.43 (0.13) | 0.57 (0.13) | 1.34 (0.24) | 2.53 | 1.00 |
| P19 | Hemoglobin subunit alpha HBA1 | 8552.23 | 1.57 (0.02) | 0.43 (0.02) | 1.88 (0.04) | 3.67 | 1.00 |
| P20 | Hemoglobin subunit beta HBB | 91.85 | 0.65 (0.05) | 1.35 (0.05) | −1.07 (0.08) | 0.48 | 0.00 |
| P21 | Hemoglobin subunit delta HBD | 42.06 | 1.94 (0.02) | 0.06 (0.02) | 5.05 (0.31) | 33.12 | 1.00 |
| P22 | Keratin type I cytoskeletal 9 KRT9 | 340.12 | 1.61 (0.13) | 0.39 (0.13) | 2.05 (0.27) | 4.14 | 1.00 |
| Keratin type I cytoskeletal 9 KRT9 | 190.36 | 1.60 (0.26) | 0.40 (0.26) | 2.06 (0.62) | 4.18 | 1.00 | |
| P23 | Keratin type II cytoskeletal 1 KRT1 | 55.74 | 1.62 (0.06) | 0.38 (0.06) | 2.08 (0.14) | 4.22 | 1.00 |
| P24 | POTE ankyrin domain family member F POTEF | 101.00 | 1.47 (0.07) | 0.53 (0.07) | 1.49 (0.14) | 2.80 | 1.00 |
| P25 | Putative beta-actin-like protein 3 POTEKP | 101.00 | 1.47 (0.09) | 0.53 (0.09) | 1.47 (0.16) | 2.77 | 1.00 |
| P26 | RNA-binding protein 25 RBM25 | 29.17 | 1.57 (0.12) | 0.43 (0.12) | 1.86 (0.25) | 3.63 | 1.00 |
| P27 | Splicing Regulatory glutamine/Lysine-rich protein 1 SREK1 | 79.89 | 1.41 (0.26) | 0.59 (0.26) | 1.28 (0.48) | 2.44 | 1.00 |
| P28 | Tetratricopeptide repeat protein 37 TTC37 | 443.53 | 1.45 (0.21) | 0.55 (0.21) | 1.44 (0.42) | 2.72 | 1.00 |
| Tetratricopeptide repeat protein 37 TTC37 | 449.05 | 1.46 (0.18) | 0.54 (0.18) | 1.47 (0.36) | 2.77 | 1.00 | |
| P29 | Triosephosphate isomerase TPI1 | 475.34 | 1.39 (0.25) | 0.61 (0.25) | 1.23 (0.41) | 2.34 | 0.97 |
| Triosephosphate isomerase TPI1 | 475.34 | 1.41 (0.22) | 0.59 (0.22) | 1.28 (0.40) | 2.44 | 0.97 | |
| Triosephosphate isomerase TPI1 | 576.90 | 1.43 (0.19) | 0.57 (0.19) | 1.34 (0.37) | 2.53 | 1.00 |
a
p-Value corrected by false discovery rate.