Table 2.

Main functional pathways associated with the 29 proteins identified as differentials between melasma and perilesional skin.

Functions	Involved proteins	n (%)	FDRa
1. Canonical glycolysis	p16, p29	2 (7)	<0.0001
2. Gluconeogenesis	p16, p29	2 (7)	<0.0001
3. Fibrinolysis	p8, p15, p23	2 (10)	<0.0001
4. Platelet degranulation	p2, p5, p6, p15, p16	5 (17)	<0.0001
5. Regulation of body fluids	p2, p5, p6, p8, p15, p16, p21, p22, p23	8 (28)	<0.0001
6. Oxygen transport	p7, p19, p20, p21	4 (14)	<0.0001
7. Vesicle-mediated transport	p2, p5, p6, p10, p14, p15, p16, p19, p20	9 (31)	<0.0001
8. Platelet activation	p5, p6, p15, p16	4 (14)	<0.0001
9. Positive regulation of cell adhesion	p15	1 (3)	0.0001
10. Hemostasis	p2, p5, p6, p15, p16, p21	6 (20)	0.0001
11. Platelet aggregation	p2, p15	2 (7)	0.0002
12. Plasminogen activation	p15	1 (3)	0.0003
13. Single-organism transport	p2, p5, p6, p7, p8, p10, p11, p12, p14, p15, p16, p19, p20, p21	14 (48)	0.0004
14. Blood clotting	p2, p5, p6, p15, p16, p21	6 (21)	0.0008
15. Error-prone translesion synthesis	p13	1 (3)	0.0010
16. Protein activation cascade	p15, p23	2 (7)	0.0014
17. Retinal homeostasis	p2, p5, p23, p24	4 (14)	0.0015
18. Down-regulation of trauma response	p8, p10, p15	3 (10)	0.0015
19. Up-regulation of exocytosis	p14, p15	2 (7)	0.0016
20. Regulation of exocytosis	p10, p14, p15	3 (10)	0.0017
21. Down-regulation of endothelial cell apoptosis process	p15	1 (3)	0.0022
22. Blood clotting, fibrin clot formation	p15	1 (3)	0.0024
23. Down-regulation of the extrinsic apoptosis signaling pathway through the receptor death domain	p15	1 (3)	0.0024
24. Transport	p2, p4, p5, p6, p7, p10, p11, p12, p15, p16, p19, p20, p21	13 (45)	0.0029
25. Monocarboxylic Acid Metabolic Process	p5, p16, p29	3 (10)	0.0030
26. Regulation of adhesion-dependent cell spread	p15	1 (3)	0.0033
27. Wound healing	p2, p5, p6, p15, p16, p21	6 (20)	0.0035
28. Bicarbonate transport	p11, p19, p20	3 (10)	0.0044
29. Up-regulation of vasoconstriction	p15	1 (3)	0.0044
30. Response to calcium ion	p2	1 (3)	0.0075
31. Regulation of transport by vesicles	p8, p10, p14, p15	4 (14)	0.0083
32. Secretion	p5, p6, p8, p15, p16	5 (17)	0.0092
33. Down-regulation by external stimuli	p8, p10, p15	3 (10)	0.0098
34. Response to stress	p2, p5, p6, p13, p16, p19, p20, p21, p23	9 (31)	0.0100

^aFalse discovery rate estimated according to the number of proteins expected for the function.