Table 1. Characteristics of the Study Population by Thrombocytopenia and Reception of Platelet Transfusion.
| Characteristic | Neonates, No./total No. (%) | |||||
|---|---|---|---|---|---|---|
| Overall (N = 1221) | By thrombocytopeniaa | By platelet transfusion | ||||
| With (n = 452) | Without (n = 767) | Received ≥1 (n = 94) | Received 0 (n = 1127) | |||
| Sex | ||||||
| Male | 731/1221 (59.9) | 286/452 (63.3) | 445/767 (58.0) | 56/94 (59.6) | 675/1127 (59.9) | |
| Female | 490/1221 (40.1) | 166/452 (36.7) | 322/767 (42.0) | 38/94 (40.4) | 452/1127 (40.1) | |
| Weight at birth, g | ||||||
| Median (IQR) | 1575.0 (1250.0-1940.0) | 1300.0 (1060.0-1565.0) | 1730.0 (1430.0-2112.0) | 1060.0 (930.0-1290.0) | 1600.0 (1305.0-1980.0) | |
| Strata | ||||||
| <1000 | 95/1221 (7.8) | 73/452 (16.2) | 22/767 (2.9) | 32/94 (34.0) | 63/1127 (5.6) | |
| 1000-1499 | 442/1221 (36.2) | 242/452 (53.5) | 200/767 (26.1) | 54/94 (57.4) | 388/1127 (34.4) | |
| 1500-2499 | 610/1221 (50.0) | 128/452 (28.3) | 481/767 (62.71) | 6/94 (6.4) | 604/1127 (53.6) | |
| 2500-3999 | 74/1221 (6.1) | 9/452 (2.0) | 64/767 (8.3) | 2/94 (2.1) | 72/1127 (6.4) | |
| Gestational age | ||||||
| Median (IQR), wk | 31.0 (29.0-33.0) | 30.0 (28.0-31.0) | 31.0 (30.0-33.0) | 28.0 (27.0-30.0) | 31.0 (29.0-33.0) | |
| Strata | ||||||
| <28 wk 0 d | 103/1221 (8.4) | 73/452 (16.2) | 30/767 (3.9) | 36/94 (38.3) | 67/1127 (5.9) | |
| 28 wk 0 d to 31 wk 6 d | 663/1221 (54.3) | 282/452 (62.4) | 381/767 (49.7) | 52/94 (55.3) | 611/1127 (54.2) | |
| 32 wk 0 d to 33 wk 6 d | 283/1221 (23.2) | 60/452 (13.3) | 222/767 (28.9) | 0/94 (0) | 283/1127 (25.1) | |
| 34 wk 0 d to 36 wk 6 d | 172/1221 (14.1) | 37/452 (8.2) | 134/767 (17.5) | 6/94 (6.4) | 166/1127 (14.7) | |
| Congenital disorder | 147/1221 (12.1) | 62 (13.7) | 85/767 (11.1) | 20/94 (21.3) | 127/1127 (11.3) | |
| Singleton | 990/1221 (81.1) | 353 (78.1) | 635/767 (82.8) | 72/94 (76.6) | 918/1127 (81.5) | |
| Apgar score ≤7 | ||||||
| 1-min | 316/1215 (26.0) | 172/450 (38.2) | 142/763 (18.6) | 53/94 (56.4) | 263/1121 (23.5) | |
| 5-min | 123/1214 (10.1) | 68/450 (15.1) | 54/762 (7.1) | 22/94 (23.4) | 101/1120 (9.0) | |
| 10-min | 69/1202 (5.7) | 44/448 (9.8) | 24/752 (3.2) | 12/93 (12.9) | 57/1109 (5.1) | |
| Cesarean delivery | 799/1221 (65.4) | 297/452 (65.7) | 500/767 (65.2) | 52/94 (55.3) | 747/1127 (66.3) | |
| Maternal preeclampsia | 183/1221 (15.0) | 109/452 (24.1) | 74/767 (9.6) | 28/94 (29.8) | 155/1127 (13.8) | |
| Pregnancy-induced hypertension | 50/1221 (4.1) | 27/452 (6.0) | 23/767 (3.0) | 6/94 (6.4) | 44/1127 (3.9) | |
| Antenatal steroids given | 745/1221 (61.6) | 261/452 (58.1) | 484/767 (63.7) | 57/94 (62.0) | 688/1127 (61.5) | |
| Intrauterine distress | 55/1221 (4.5) | 32/452 (7.1) | 23/767 (3.0) | 5/94 (5.3) | 50/1127 (4.4) | |
| Maternal age, median (IQR), y | 31.0 (28.0-35.0) | 32.0 (28.0-35.0) | 31.0 (28.0-35.0) | 33.0 (29.0-36.0) | 31.0 (28.0-35.0) | |
| High-risk pregnancyb | 290/1221 (23.8) | 124/452 (27.4) | 166/767 (21.6) | 33/94 (35.1) | 257/1127 (22.8) | |
| Premature rupture of membrane | 224/1221 (18.4) | 49/452 (10.8) | 175/767 (22.8) | 3/94 (3.2) | 221/1127 (19.6) | |
| Ventilated later than birthday | 70/1221 (5.7) | 24/452 (5.3) | 46/767 (6.0) | 7/94 (7.4) | 63/1127 (5.6) | |
| Sepsisc | 51/1221 (4.2) | 38/452 (8.4) | 13/767 (1.7) | 16/94 (17.0) | 35/1127 (3.1) | |
| NECd | 6/1221 (0.5) | 2/452 (0.4) | 4/767 (0.5) | 1/94 (1.1) | 5/1127 (0.4) | |
| Length of hospital stay, median (IQR), d | 35.0 (19.0-52.0) | 48.0 (27.5-70.0) | 28.0 (16.0-44.0) | 66.5 (31.0-93.0) | 33.0 (18.0-50.0) | |
| Any grade of IVH | 263/1221 (21.5) | 156/452 (34.5) | 107/767 (14.0) | 50/94 (53.2) | 213/1127 (18.9) | |
| Grade 3 or 4 IVH | 81/1221 (6.6) | 61/452 (13.5) | 20/767 (2.6) | 26/94 (27.7) | 55/1127 (4.9) | |
| In-hospital mortality | 80/1221 (6.6) | 55/452 (12.2) | 23/767 (3.0) | 18/94 (19.2) | 62/1127 (5.5) | |
Abbreviations: IVH, intraventricular hemorrhage; NEC, necrotizing enterocolitis.
a
Thrombocytopenia was defined as any platelet count less than 150 × 103/μL during hospital stay. Results for 2 infants were missing because they did not receive any blood test during hospital stay. Percentages may not add to 100% due to rounding.
b
High-risk pregnancy was defined as maternal age less than 17 or greater than 35 years old.
c
Sepsis was defined by a positive blood culture.
d
NEC was defined as stage 2A or higher, according to modified Bell staging criteria.