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. 2022 Oct 6;9:984695. doi: 10.3389/fnut.2022.984695

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Copyright © 2022 Rehman, Siddiqui, Farooqui, Alam, Gul, Ahmad, Asim, Khan, Xin, Zexu, Song Ju, Xin, Lei and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Experimental plan and design. The TD2M mouse model was developed by giving a HFD for 4 weeks, followed by intraperitoneal injections of STZ at 60 mg/kg on an overnight fast every fifth day for 8 weeks. The T2DM mice were divided into five groups (n = 8 in each group): no MEP treatment: 200 mg/kg metformin (MET); 200 mg/kg MEP low dose (MEPL); 400 mg/kg MEP medium dose (MEPM); and 600 mg/kg MEP high dose (MEPH). The 16 control mice were divided into two groups (n = 8). One was given PBS as control (CON), and the other was given 200 mg/kg MEP.