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. 2022 Oct 6;9:984695. doi: 10.3389/fnut.2022.984695

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Copyright © 2022 Rehman, Siddiqui, Farooqui, Alam, Gul, Ahmad, Asim, Khan, Xin, Zexu, Song Ju, Xin, Lei and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Functional profile analysis of gut metabolites in T2DM mice. (A,B) COG (Clusters of Orthologous Groups) shows the metabolic pathways functional predictions and KEGG database level 3 indicated with their confidence interval ratio of differences, while p-value shows on the right side among different groups. (C) Expression of genes involved in indole biosynthesis and (D) Secondary bile acid biosynthesis. ^# indicates a significant difference compared with control (CON) group. ^##p < 0.01 vs. Control. * indicates a significant difference compared with the DM group. *p < 0.05, **p < 0.01 vs. DM.