Table 2.
Summary of the highest-correlated (ρ>0.6) radiomic-pathomic features, with radiomic features extracted from ADC.
| Radiomic feature name | Pathomic featµre name | ρ | FDR q-value | BF |
|---|---|---|---|---|
| ADC ngtdm Contrast | CD200µm ngtdm Strength | 0.739 | 1.48×10-5 | 6.46×106 |
| ADC firstorder Minimum | CD200µm ngtdm Strength | 0.729 | 1.48×10-5 | 3.15×106 |
| ADC firstorder 10Percentile | CD200µm ngtdm Strength | 0.725 | 1.48×10-5 | 2.36×106 |
| ADC firstorder Median | CD200µm ngtdm Strength | 0.698 | 4.12×10-5 | 4.06×105 |
| ADC ngtdm Contrast | MEAN Haralick ASM F0 | 0.697 | 4.12×10-5 | 3.74×105 |
| ADC firstorder Minimum | MEAN Haralick ASM F0 | 0.694 | 4.12×10-5 | 3.16×105 |
| ADC gldm LDLGLE | CD100µm glrlm RunVariance | 0.693 | 4.12×10-5 | 3.00×105 |
| ADC glszm LALGLE | CD100µm glrlm RunVariance | 0.693 | 4.12×10-5 | 2.93×105 |
| ADC firstorder Mean | CD200µm ngtdm Strength | 0.692 | 4.12×10-5 | 2.75×105 |
| ADC ngtdm Contrast | MEAN Haralick IMOC2 F12 | -0.691 | 4.12×10-5 | 2.59×105 |
| ADC ngtdm Busyness | CD100µm glrlm RunVariance | 0.69 | 4.12×10-5 | 2.42×105 |
| ADC glszm ZoneVariance | CD100µm glrlm RunVariance | 0.687 | 4.12×10-5 | 2.07×105 |
| ADC glcm DifferenceVariance | MEAN Haralick ASM F0 | 0.687 | 4.12×10-5 | 2.05×105 |
| ADC firstorder 10Percentile | MEAN Haralick ASM F0 | 0.687 | 4.12×10-5 | 2.01×105 |
| ADC glcm DifferenceVariance | CD200µm ngtdm Strength | 0.679 | 6.01×10-5 | 1.31×105 |
| ADC firstorder Median | MEAN Haralick ASM F0 | 0.676 | 6.67×10-5 | 1.09×105 |
| ADC glcm Imc2 | CD100µm glrlm RunVariance | -0.675 | 6.67×10-5 | 1.05×105 |
| ADC firstorder Mean | MEAN Haralick ASM F0 | 0.672 | 7.40×10-5 | 9.00×104 |
| ADC firstorder 90Percentile | CD200µm ngtdm Strength | 0.66 | 1.44×10-4 | 4.52×104 |
| ADC firstorder 90Percentile | MEAN Haralick ASM F0 | 0.656 | 1.67×10-4 | 3.71×104 |
| ADC gldmDependenceVariance | CD100µm glrlm RunVariance | 0.655 | 1.67×10-4 | 3.55×104 |
| ADC firstorder Minimum | MEAN Haralick IMOC2 F12 | -0.654 | 1.67×10-4 | 3.27×104 |
| ADC glszm LALGLE | CD150µm glszm LALGLE | 0.653 | 1.67×10-4 | 3.17×104 |
| ADC gldm LDLGLE | CD150µm glszm LALGLE | 0.653 | 1.67×10-4 | 3.14×104 |
| ADC ngtdm Busyness | CD150µm glszm LALGLE | 0.648 | 2.05×10-4 | 2.48×104 |
| ADC glszm ZoneVariance | CD150µm glszm LALGLE | 0.644 | 2.44×10-4 | 2.03×104 |
| ADC glcm DifferenceVariance | MEAN Haralick IMOC2 F12 | -0.641 | 2.72×10-4 | 1.76×104 |
| ADC glrlm RunVariance | CD100µm glrlm RunVariance | 0.64 | 2.78×10-4 | 1.67×104 |
| ADC firstorder 10Percentile | CD100µm ngtdm Strength | 0.634 | 3.58×10-4 | 1.27×104 |
| ADC glcm Imc2 | CD150µm glszm LALGLE | -0.63 | 4.39×10-4 | 1.01×104 |
| ADC firstorder Minimum | CD100µm ngtdm Strength | 0.628 | 4.46×10-4 | 9.50×103 |
| ADC firstorder 10Percentile | MEAN Haralick IMOC2 F12 | -0.628 | 4.46×10-4 | 9.29×103 |
| ADC glszm GLNUN | CD100µm glrlm RunVariance | 0.627 | 4.46×10-4 | 9.10×103 |
| ADC glszm GLNUN | CD150µm glszm LALGLE | 0.622 | 5.71×10-4 | 6.98×103 |
| ADC ngtdm Contrast | CD100µm ngtdm Strength | 0.621 | 5.87×10-4 | 6.62×103 |
| ADC glcm ClusterProminence | MEAN Haralick ASM F0 | 0.614 | 7.70×10-4 | 4.98×103 |
| ADC firstorder Median | CD100µm ngtdm Strength | 0.613 | 7.74×10-4 | 4.83×103 |
| ADC ngtdm Complexity | CD50µm glcm Contrast | 0.61 | 8.56×10-4 | 4.21×103 |
| ADC gldmDependenceVariance | CD150µm glszm LALGLE | 0.61 | 8.56×10-4 | 4.11×103 |
| ADC firstorder TotalEnergy | CD50µm glcm Contrast | 0.61 | 8.56×10-4 | 4.07×103 |
| ADC glcm InverseVariance | CD100µm glrlm RunVariance | 0.609 | 8.64×10-4 | 3.94×103 |
| ADC firstorder Mean | CD100µm ngtdm Strength | 0.607 | 9.13×10-4 | 3.66×103 |
| ADC firstorder Maximum | MEAN Haralick ASM F0 | 0.606 | 9.37×10-4 | 3.42×103 |
| ADC firstorder Median | MEAN Haralick IMOC2 F12 | -0.606 | 9.37×10-4 | 3.41×103 |
| ADC gldm LDLGLE | CD100µm glrlm LongRunEmphasis | 0.604 | 9.43×10-4 | 3.23×103 |
| ADC firstorder Mean | MEAN Haralick IMOC2 F12 | -0.604 | 9.43×10-4 | 3.22×103 |
| ADC glszm LALGLE | CD100µm glrlm LongRunEmphasis | 0.604 | 9.43×10-4 | 3.19×103 |
| ADC ngtdm Busyness | CD100µm glrlm LongRunEmphasis | 0.602 | 9.95×10-4 | 2.97×103 |
| ADC glrlm RunVariance | CD150µm glszm LALGLE | 0.601 | 1.02×10-3 | 2.84×103 |
| ADC glszm ZoneVariance | CD100µm glrlm LongRunEmphasis | 0.6 | 1.04×10-3 | 2.73×103 |
ADC, Apparent Diffusion Coefficient; CD, Cellular Density; FDR, False Discovery Rate; BF, Bayes Factor; LDLGLE, Large Dependence Low Gray Level Emphasis; LALGLE, Large Area Low Gray Level Emphasis; GLNUN, Gray level non uniformity normalized; LDLGLE, Large Dependence Low Gray Level Emphasis; ASM, Angular Second Moment; IMOC, Information Measure Of Correlation; glcm, gray level co-occurrence matrix; glszm, Gray Level Size Zone Matrix; ngtdm, Neighbouring Gray Tone Difference Matrix; glrlm, Gray Level Run Length Matrix.