TABLE 3.

Minimum inhibitory concentration (MIC) determination of six main antibiotics used for the treatment of P. aeruginosa infection, ciprofloxacin (CIP), piperacillin (PIP), tobramycin (TOB), colistin (COL), meropenem (MER), and gentamicin (GEN), against wild-type PAO1 and 10 strains of phage-resistant isolates.

Strains	CLSI susceptibility (MIC, μg/mL)
	CIP	PIP	TOB	COL	MER	GEN
PAO1	S (0.08)	S (2.50)	S (1.25)	S (1.25)	S (0.62)	S (2.50)
W10	S (0.04)	S (5.00)	S (1.25)	S (0.16)	S (1.25)	S (1.25)
W11	S (0.04)	S (2.50)	S (1.25)	S (1.25)	S (1.25)	S (1.25)
W12	S (0.04)	S (2.50)	S (1.25)	S (1.25)	S (1.25)	S (1.25)
W132	S (0.08)	S (5.00)	S (2.50)	S (0.16)	S (0.62)	S (1.25)
W138	S (0.04)	S (5.00)	S (2.50)	S (0.31)	S (0.31)	S (2.50)
W139	S (0.04)	S (5.00)	S (2.50)	S (0.31)	S (0.62)	S (1.25)
W140	S (0.04)	S (5.00)	S (2.50)	S (0.31)	S (0.62)	S (1.25)
W141	S (0.04)	S (5.00)	S (2.50)	S (0.31)	S (0.31)	S (1.25)
W142	S (0.04)	S (5.00)	S (2.50)	S (0.62)	S (0.31)	S (2.50)
W143	S (0.04)	S (2.50)	S (1.25)	S (1.25)	S (0.62)	S (2.50)

The test was performed in triplicate and categorized based on the drug susceptibility level; S, sensitive; I, intermediate; R, resistant, according to CLSI standards (CLSI, 2020). Gray (wild-type MIC level), yellow (2X increase), light green (2X decrease), medium green (4X decrease), and dark green (8X decrease).