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. 2022 Oct 6;12:1020349. doi: 10.3389/fonc.2022.1020349

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Copyright © 2022 Ma, Lin, Liu, Wei, Ji, Shi, Lin and Zhou

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The tumors were segmented on venous phase, three groups of different marginal and internal regions were formed by retracting the tumor margin by 1, 2, and 3 mm on the representative section. The red areas represent the maximum slice of the tumor (ROI). The blue areas represent the rings with the thickness of 1-3mm in the marginal regions of the tumor (MROI), respectively. The hot-pink areas represent the remaining internal regions of the tumor (IROI) after removing the rings, respectively. ROI, regions of interest. MROI, the marginal areas of tumor. IROI, the interior areas of tumor.