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. 2022 Oct 6;12:885011. doi: 10.3389/fonc.2022.885011

Table 1.

Clinical characteristics of CD5+ and CD5− non-DE DLBCL patients. .

Characteristic CD5+ (n = 48) 2.1.1.1 CD5− (n = 481) p
Median age, years (range) 57 (25–90) 58 (16–90)
Gender 0.079
Men
Women
32 (66.7%)
16 (33.3%)
257 (53.4%)
224 (46.6%)
Ann Arbor, n (%) 0.021
I–II 21 (43.7%) 293 (60.9%)
III–IV 27 (56.3%) 188 (39.1%)
LDH, n (%) 0.241
> Normal 26 (54.2%) 218 (45.3%)
≤ Normal 22 (45.8%) 263 (54.7%)
ECOG, n (%) 0.330
< 2 43 (89.6%) 449 (93.3%)
≧ 2 5 (10.4%) 32 (6.7%)
IPI, n (%) 0.010
0–2 27 (56.2%) 355 (73.8%)
3–5 21 (43.8%) 126 (26.2%)
Age > 60 years, n (%) 19 (39.6%) 202 (42%) 0.747
Extranodal sites, n (%) 0.231
≧ 2 15 (31.3%) 113 (23.5%)
< 2 33 (68.7%) 368 (76.5%)
Cell of origin 0.443
Non-GCB 30 (62.5%) 373 (56.8%)
GCB 18 (37.5%) 208 (43.2%)
Response 0.413
CR 38 (79.2%) 403 (83.8%)
Non-CR 10 (20.8%) 78 (16.2%)
Bone marrow involvement, n (%) 8 (16.7%) 31 (6.4%) 0.018
CNS relapse, n (%) 3 (6.3%) 6 (1.3%) 0.040

DLBCL, diffuse large B-cell lymphoma; LDH, lactate dehydrogenase; ECOG, Eastern Cooperative Oncology Group; IPI, international prognostic index; GCB, germinal center B-cell; CR, complete remission; CNS, central nervous system.