Table 1.
Patients' characteristics.
| Characteristics | Participants | IGFBP3 | IGF1 | |||||
|---|---|---|---|---|---|---|---|---|
| ng/mL | P | ng/mL | P | |||||
| N | 131 | 498.6 | (382.7–604.7) | 39.0 | (24.8–62.9) | |||
| Male | 86 | (66) | 443.3 | (333.8–565.3) | <0.01 | 41.4 | (24.4–65.5) | 0.119 |
| Female | 45 | (34) | 562.9 | (468.4–637.2) | 34.0 | (22.1–58.5) | ||
| Age, years (range) | 66 | (46–86) | - | - | ||||
| BMI, kg/m2 (range) | 24.1 | (15.2–36.1) | - | - | ||||
| Underweight | 9 | (7) | 505.3 | (445.5–591.7) | 0.343 | 26.7 | (19.5–41.5) | 0.065 |
| Normal weight | 67 | (51) | 469.3 | (348.6–570.1) | 35.9 | (23.8–59.8) | ||
| Overweight | 42 | (32) | 528.8 | (401.1–631.5) | 40.3 | (33.3–73.1) | ||
| Obesity | 13 | (10) | 564.2 | (449.9–629.0) | 54.9 | (24.8–66.0) | ||
| Histology | ||||||||
| Adenocarcinoma | 74 | (56) | 519.2 | (394.0–626.4) | 0.305 | 45.5 | (25.0–70.8) | 0.196 |
| Squamous cell carcinoma | 39 | (30) | 461.9 | (367.2–568.5) | 34.7 | (24.0–49-6) | ||
| NSCLC, NOS | 8 | (6) | 490.9 | (322.4–620.7) | 38.9 | (23.2–95.0) | ||
| SCLC | 10 | (8) | 460.3 | (395.4–602.1) | 33.0 | (24.7–46.6) | ||
| Grading | ||||||||
| 1 | 8 | (7) | 642.1 | (461.1–731.4) | 0.032 | 57.2 | (46.0–86.8) | 0.165 |
| 2 | 49 | (41) | 516.5 | (398.4–605.9) | 38.0 | (28.7–61.0) | ||
| 3 | 53 | (44) | 461.9 | (349.7–588.2) | 40.3 | (20.9–66.5) | ||
| 4 | 10 | (58) | 460.3 | (395.4–602.1) | 33.0 | (24.7–46.6) | ||
| Tumor stage | ||||||||
| I | 17 | (13) | 536.4 | (386.4–701.6) | 0.039 | 47.8 | (16.5–54.1) | 0.605 |
| II | 6 | (5) | 638.7 | (543.0–694.0) | 46.8 | (36.7–112.1) | ||
| III | 25 | (19) | 483.2 | (431.4–635.3) | 37.6 | (24.6–54.7) | ||
| IV | 83 | (63) | 471.0 | (354.2–598.5) | 39.0 | (24.0–67.3) | ||
LC patients' characteristics. Data are number (N) and percentage (%) or median with interquartile range (IQR, Q1-Q3), unless otherwise defined. Student's t-test or Mann-Whitney-U test were used to compared two groups with each other, while one-way analysis of variance or Kruskal-Wallis test to compare more than two groups. BMI, Body mass index; IGF1, insulin-like growth factor; IGFBP3, insulin-like growth factor binding protein 3; NSCLC, non-small cell lung cancer; NOS, not otherwise specified; P, P-value; SCLC, small cell lung cancer.