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Macrophage autophagy alleviates lung fibrosis. In AMs, autophagy can reduce crystalline silica-associated apoptosis and mtROS, both of which could promote cytokines such as IL-8 and HMGB1. With the stimulation of cytokines, type II alveolar epithelial cells could secrete ECM to cause lung fibrosis. mtROS: mitochondrial reactive oxygen species.
