Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Oct 6;13:946832. doi: 10.3389/fimmu.2022.946832

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Wen, Li, Liang, Yang, Tang and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Macrophage autophagy alleviates kidney fibrosis. Besides secreting inflammatory cytokines, macrophages could transform into LECs to promote an inflammatory environment. Macrophage autophagy could reduce macrophage transformation into LECs and cytokines secretion. The autophagy regulation target is USP19 and PINK/MFN2 pathways, and it can influence the downstream proteins to change autophagy conditions. LECs, Lymphatic Endothelial Cell.