Table 3.
Genotypes frequencies distribution and association with CHD risk.
| SNP-ID | Model | Genotype | Case (%) | Control (%) | OR (95% CI) | P | Adjusted OR (95% CI) | P |
|---|---|---|---|---|---|---|---|---|
| rs420137 | Co-dominant | CC | 290 (51.1) | 279 (44.3) | 1 | 1 | ||
| GC | 234 (41.2) | 286 (45.4) | 1.27 (1.00–1.61) | 0.049 | 1.29 (1.02–1.65) | 0.037 | ||
| GG | 44 (7.8) | 65 (10.3) | 1.54 (1.01–2.33) | 1.55 (1.02–2.36) | ||||
| Dominant | CC | 290 (51.1) | 279 (44.3) | 1 | 1 | |||
| GC-GG | 278 (48.9) | 351 (55.7) | 1.31 (1.05–1.65) | 0.019 | 1.34 (1.06–1.68) | 0.015 | ||
| Recessive | CC-GC | 524 (92.2) | 565 (89.7) | 1 | 1 | |||
| GG | 44 (7.8) | 65 (10.3) | 1.37 (0.92–2.05) | 0.124 | 1.38 (0.92–2.06) | 0.132 | ||
| Additive | – | – | – | 1.04 (0.65–1.68) | 0.013 | 1.27 (1.06–1.51) | 0.011 | |
| rs386360 | Co-dominant | AA | 301 (53) | 289 (45.9) | 1 | 1 | ||
| CA | 228 (40.1) | 283 (44.9) | 1.29 (1.02–1.64) | 0.035 | 1.31 (1.03–1.67) | 0.026 | ||
| CC | 39 (6.9) | 58 (9.2) | 1.55 (1.00–2.40) | 1.56 (1.01–2.43) | ||||
| Dominant | AA | 301 (53) | 289 (45.9) | 1 | 1 | |||
| CA-CC | 267 (47) | 341 (54.1) | 1.33 (1.06–1.67) | 0.014 | 1.35 (1.07–1.70) | 0.011 | ||
| Recessive | AA-CA | 529 (93.1) | 572 (90.8) | 1 | 1 | |||
| CC | 39 (6.9) | 58 (9.2) | 1.38 (0.90–2.10) | 0.140 | 1.38 (0.90–2.11) | 0.149 | ||
| Additive | – | – | – | 1.27 (1.06–1.52) | 0.010 | 1.28 (1.07–1.53) | 0.009 | |
| rs7763726 | C-odominant | AA | 345 (60.7) | 321 (51) | 1 | 1 | ||
| GA | 193 (34) | 264 (41.9) | 1.47 (1.16–1.87) | 0.002 | 1.50 (1.17–1.90) | 0.001 | ||
| GG | 30 (5.3) | 45 (7.1) | 1.61 (0.99–2.62) | 1.68 (1.03–2.74) | ||||
| Dominant | AA | 345 (60.7) | 321 (51) | 1 | 1 | |||
| GA-GG | 223 (39.3) | 309 (49) | 1.49 (1.18–1.87) | 7.0E-04 | 1.52 (1.21–1.92) | 4.0E-04 | ||
| Recessive | AA-GA | 538 (94.7) | 585 (92.9) | 1 | 1 | |||
| GG | 30 (5.3) | 45 (7.1) | 1.38 (0.86–2.22) | 0.186 | 1.43 (0.88–2.31) | 0.176 | ||
| Additive | – | – | – | 1.37 (1.13–1.65) | 0.001 | 1.39 (1.15–1.69) | 7.0E-04 |
CHD, coronary heart disease; SNP, single nucleotide polymorphism; OR, odds ratio; CI, confidence interval. Adjusted OR (95% CI) were calculated by logistic regression analysis with adjustments for age and gender. Bold values are statistically significant (p < 0.05).