Table 4.
FNDC1 SNPs associated with CHD risk stratified by gender and age status.
| SNP-ID | Model | Genotype | Male | Female | >62 | ≤62 | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | |||
| rs420137 | Allele | C | 1 | 1 | 1 | 1 | ||||
| G | 1.36 (0.11–1.09) | 0.006 | 1.01 (0.81–1.46) | 0.573 | 1.21 (0.95–1.55) | 0.121 | 1.29 (1.00–1.65) | 0.047 | ||
| Co-dominant | CC | 1 | 1 | 1 | 1 | |||||
| GC | 1.48 (1.10–1.99) | 0.010 | 1.00 (0.66–1.50) | 0.997 | 1.37 (0.98–1.92) | 0.142 | 1.20 (0.85–1.69) | 0.300 | ||
| GG | 1.65 (1.00–2.74) | 1.38 (0.66–2.90) | 1.32 (0.72–2.39) | 1.83 (1.01–3.31) | 0.026 | |||||
| Dominant | CC | 1 | 1 | 1 | 1 | |||||
| GC-GG | 1.51 (1.14–2.00) | 0.004 | 1.05 (0.71–1.55) | 0.814 | 1.36 (0.98–1.88) | 0.125 | 1.30 (0.94–1.80) | 0.100 | ||
| Recessive | CC-GC | 1 | 1 | 1 | 1 | |||||
| GG | 1.38 (0.85–2.25) | 0.194 | 1.38 (0.68–2.82) | 0.372 | 1.12 (0.63–1.99) | 0.649 | 1.68 (0.95–2.99) | 0.043 | ||
| Additive | – | 1.36 (1.09–1.69) | 0.006 | 1.10 (0.80–1.50) | 0.562 | 1.23 (0.96–1.59) | 0.162 | 1.29 (1.00–1.65) | 0.031 | |
| rs386360 | Allele | A | 1 | 1 | 1 | 1 | ||||
| C | 1.36 (1.09–1.69) | 0.007 | 1.11 (0.83–1.50) | 0.498 | 1.24 (0.96–1.58) | 1.28 (0.13–1.00) | 0.051 | |||
| Co-dominant | A/A | 1 | 1 | 1 | 1 | |||||
| C/A | 1.44 (1.06–1.93) | 0.017 | 1.12 (0.75–1.68) | 0.502 | 1.39 (0.99–1.95) | 0.124 | 1.22 (0.87–1.72) | 0.279 | ||
| C/C | 1.73 (1.01–2.94) | 1.31 (0.60–2.84) | 1.35 (0.72–2.52) | 1.79 (0.96–3.33) | 0.027 | |||||
| Dominant | A/A | 1 | 1 | 1 | 1 | |||||
| C/A-C/C | 1.48 (1.12–1.96) | 0.006 | 1.14 (0.77–1.69) | 0.508 | 1.38 (1.00–1.91) | 0.105 | 1.30 (0.94–1.80) | 0.095 | ||
| Recessive | A/A-C/A | 1 | 1 | 1 | 1 | |||||
| C/C | 1.47 (0.88–2.47) | 0.142 | 1.23 (0.58–2.61) | 0.584 | 1.15 (0.63–2.11) | 0.601 | 1.64 (0.89–3.00) | 0.044 | ||
| Additive | – | 1.37 (1.09–1.70) | 0.006 | 1.13 (0.82–1.55) | 0.445 | 1.26 (0.97–1.63) | 0.131 | 1.29 (1.00–1.66) | 0.030 | |
| rs7763726 | Allele | A | 1 | 1 | 1 | 1 | ||||
| G | 1.58 (0.12–1.25) | < 0.001 | 1.09 (0.80–1.48) | 0.287 | 1.33 (1.03–1.73) | 0.031 | 1.40 (0.14–1.08) | 0.013 | ||
| Co-dominant | A/A | 1 | 1 | 1 | 1 | |||||
| A/G | 1.87 (1.38–2.53) | < 0.001 | 0.98 (0.65–1.48) | 0.337 | 1.45 (1.04–2.04) | 0.088 | 1.52 (1.08–2.15) | 0.020 | ||
| G/G | 1.78 (0.96–3.29) | 1.48 (0.66–3.30) | 1.61 (0.80–3.24) | 1.75 (0.88–3.49) | ||||||
| Dominant | A/A | 1 | 1 | 1 | 1 | |||||
| G/A-G/G | 1.86 (1.39–2.48) | < 0.001 | 1.04 (0.71–1.54) | 0.831 | 1.47 (1.06–2.04) | 0.055 | 1.55 (1.12–2.16) | 0.009 | ||
| Recessive | A/A-G/A | 1 | 1 | 1 | 1 | |||||
| G/G | 1.39 (0.76–2.56) | 0.283 | 1.49 (0.68–3.26) | 0.317 | 1.37 (1.00–1.93) | 0.316 | 1.49 (0.76–2.94) | 0.182 | ||
| Additive | – | 1.59 (1.25–2.03) | < 0.001 | 1.10 (0.80–1.50) | 0.562 | 1.36 (1.04–1.78) | 0.050 | 1.42 (1.09–1.86) | 0.008 | |
CHD, coronary heart disease; SNP, single nucleotide polymorphism; OR, odds ratio; CI, confidence interval.
OR (95% CI) values were calculated by logistic regression analysis with adjustments for gender and age.
Bold values are statistically significant (p < 0.05).