TABLE 1.
Antibody levels in 3-year-old Gambian children immunized with EZ medium-titer (104.6-PFU/dose) vaccine at 4 months of age or Schwarz standard-titer (103.7-PFU/dose) vaccine at 9 months of age
| Vaccine and group | Median (range)
|
||
|---|---|---|---|
| % ADCCa | Reciprocal titer
|
||
| PNTb | HIAc | ||
| EZ | |||
| Males | 13.2 | 160 | 32 |
| Females | 9.9 | 160 | 96 |
| Total | 12.4 (4.1–37.1) | 160 (40–1,280) | 64 (8–4,096) |
| Schwarz | |||
| Males | 11.0 | 640 | 96 |
| Females | 10.9 | 1,280 | 128 |
| Total | 11.0 (5.8–21.7) | 640 (80–1,280) | 128 (8–4,096) |
a
65 samples were tested (15 from EZ females, 18 from EZ males, 15 from Schwarz females, and 17 from Schwarz males). Values reflect cytotoxicity obtained with sera at a 1:100 dilution.
b
53 samples were tested (13 from EZ females, 15 from EZ males, 11 from Schwarz females, and 14 from Schwarz males). PNT titers are significantly higher for Schwarz recipients than for EZ recipients (P < 0.001).
c
60 samples were tested (12 from EZ females, 17 from EZ males, 15 from Schwarz females, and 16 from Schwarz males).