Fig. 1 |. Schematic overview of study flow, including main data-analysis steps, result summary and conclusions.

TFs, transcriptions factors; GRN78, cross-tissue GRN78 identified in the STARNET study; GRN98, liver-specific GRN98 identified in the STARNET study; EF, endocrine factor; KDs, key disease drivers; H2, broad-sense heritability contribution.