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. Author manuscript; available in PMC: 2022 Oct 20.
Published in final edited form as: Nat Cardiovasc Res. 2022 Jan 12;1(1):85–100. doi: 10.1038/s44161-021-00009-1

Extended Data Fig. 8 |. A tutorial of the STARNET browser.

Extended Data Fig. 8 |

The STARNET browser (http://starnet.mssm.edu) brings the mechanistic framework of GRNs to the bench-side of the individual CMD and CAD scientist for immediate use. In the displayed example, 304 lead SNPs identified by the most recent GWAS of CAD28 are queried using the STARNET browser. Six of these lead SNPs are found as eQTLs in GRN39. Together with plasma LDL/HDL levels, these lead SNPs regulate the activity of GRN39 that in turn governs the extracellular matrix organization in the coronary arteries, thereby affecting CAD development (Fig. 3).