Skip to main content
. Author manuscript; available in PMC: 2022 Oct 20.
Published in final edited form as: Nat Cardiovasc Res. 2022 Jan 12;1(1):85–100. doi: 10.1038/s44161-021-00009-1

Fig. 6 |. Adipose endocrine factors in the cross-tissue GRN78 targeting liver-specific GRN98 are associated with liver and plasma lipid and glucose levels.

Fig. 6 |

a, Scatterplots showing linear correlations of eigengene values of GRN78 and GRN98 with BMI and plasma leptin, HbA1c and total cholesterol levels. Pearson correlation, two-sample t-tests. b, Radar plots comparing the top five GO enrichments for tissue-stratified genes in GRN78 and GRN98. c, Heatmap showing Pearson correlations of GRN78 endocrine candidates (13 unique genes) with eigengene values of GRN98 in the STARNET study and in independent SF, VAF and liver microarray and RNA-seq data from HMDP mice fed a chow or high-fat (HF) diet25, GTEx32 and a morbid obesity cohort33. The official NCBI Gene symbol for SSPO is SSPOP. d,e, Associations of the 13 endocrine candidates with; CMD and CAD clinical phenotypes in the STARNET study (d) and, CMD phenotypes in high-fat/high-sucrose (HF/HS) fed mice in the HMDP, including plasma free fatty acid (FFA) levels and liver triglyceride (TG) and total cholesterol (TC) levels (e). Cor., correlation; NPX, Normalized Protein eXpression (Olink Inc.).