Table 1.
The percent of variant allele frequencies (VAF%) of KRAS mutations in tumor tissues prepared by bulk, coring, and LMD techniques
| Case | VAF (bulk)% | VAF (core)% | VAF (LMD)% | Fold changes (core/bulk) | Fold changes (LMD/bulk) | KRAS mutations |
|---|---|---|---|---|---|---|
| C3L-01032 | 34.2 | 48.1 | 45.9 | 1.4 | 1.3 | p.G12D |
| C3L-01160 | 29.5 | 51.8 | 30.6 | 1.8 | 1.0 | p.G12D |
| C3N-01897 | 18.5 | 20.3 | 26.7 | 1.1 | 1.4 | p.G12R |
| C3N-02997 | 15.1 | 9.4 | 20.0 | 0.6 | 1.3 | p.G12V |
| C3N-02591 | 10.3 | 9.1 | 21.2 | 0.9 | 2.1 | p.G12R |
| C3N-02590 | 7.7 | 12.2 | 33.6 | 1.6 | 4.4 | p.G12V |
| C3L-01158 | 2.7 | 4.4 | 17.3 | 1.6 | 6.4 | p.G12R |
| C3L-03624 | 0.8 | 0.3 | 6.0 | 0.4 | 7.6 | p.Q61H |
The fold changes of VAFs of coring and LMD compared to VAF of the matched bulk tumors were included to show the neoplastic cellularity enrichment efficiencies by the coring and LMD methods