Table2.
The roles and mechanisms of TRIM family proteins in mediating chemoresistance
| TRIM family | Cancer types | Chemotherapy to | Mechanisms | References |
|---|---|---|---|---|
| Overexpression of TRIM7 | Osteosarcoma | DOX (Doxorubicin hydrochloride) MTX (Methotrexate) | Promotes the Ubiquitination of BRMS1 (breast cancer metastasis suppressor 1) | [102] |
| Downregulation of TRIM10 | Osteosarcoma | Cisplatin | activates the NF-κB signaling pathway | [244] |
| Overexpression of TRIM58 | Breast cancer | DOX | inactivates p53/p21 axis | [161] |
| Overexpression of TRIM8 | CRC and ccRCC | Cisplatin | Inhibits the stability and activity of P53 | [272] |
| Overexpression of TRIM24 | Gastric cancer | 5-FU | Upregulates cyclin D1 and Akt phosphorylation | [273] |
| Overexpression of TRIM17 or Downregulation of TRIM28 | Melanoma | DOX | Reduces BCL2A1 (B-cell lymphoma 2-related protein A1) protein levels | [274] |
| Downregulation of TRIM72 | Uveal melanoma | Dacarbazine (DTIC) | Inhibits ubiquitination of MGMT (O6-methylguanine DNA methyl transferase) | [275] |
| Overexpression of TRIM29 | LUAD | Cisplatin | NA | [276] |
| Overexpression of TRIM23 | LUAD | Cisplatin | Regulates glucose metabolism via NF-κB/GLUT1/3 axis | [95] |
| Overexpression of TRIM46 | LUAD | Cisplatin | Enhances glycolysis | [97] |
| Downregulation of TRIM65 | NSCLC | Cisplatin | Regulates miR-138-5p | [277] |
| Overexpression of TRIM59 | NSCLC | Cisplatin | Regulates PTEN/AKT | [278] |
| Downregulation of TRIM72 | NSCLC | Cisplatin | NA | [279] |
| Overexpression of TRIM11 | Nasopharyngeal carcinoma | Multidrug | Inhibits apoptosis and modulates the Daple/β-catenin | [46] |
| Overexpression of TRIM37 | Pancreatic Cancer | 5-FU | Promoted promotes ubiquitination of PTEN and activates of the AKT-GSK-3β-β-Catenin | [59] |
| Overexpression of TRIM31 | AML | Daunorubicin | Regulates Wnt/β-catenin pathway | [235] |
| Downregulation of TRIM21 | Glioma | Temozolomide | NA | [77] |
| Overexpression of TRIM31 | Glioma | Temozolomide | Activates PI3K/Akt | [280] |
| Overexpression of TRIM47 | CRC | 5-FU | Promotes ubiquitination of SMAD4 | [215] |
| Overexpression of TRIM8 | CRC | Chemotherapy | NA | [245] |
The varied expression level of different TRIM family proteins are positively related to the chemotherapy resistance in different types of cancer. The mechanisms are listed in the table as well fluorouracil.
NA not applicable